1-(2-Hydroxy-4-methoxyphenyl)-2-phenylethanone

Base Information

• Chemical Name: 1-(2-Hydroxy-4-methoxyphenyl)-2-phenylethanone
• CAS No.: 18439-96-8
• Molecular Formula: C15H14 O3
• Molecular Weight: 242.274
• Hs Code.: 2914509090
• European Community (EC) Number: 650-985-1
• DSSTox Substance ID: DTXSID10379613
• Nikkaji Number: J1.272.360A
• Wikidata: Q82169495
• Mol file: 18439-96-8.mol

Synonyms:1-(2-hydroxy-4-methoxyphenyl)-2-phenylethanone;18439-96-8;Ethanone,1-(2-hydroxy-4-methoxyphenyl)-2-phenyl-;Oprea1_292049;SCHEMBL3811897;2-Hydroxy-4-methoxydeoxybenzoin;DTXSID10379613;WYMYJTSWNPZKHM-UHFFFAOYSA-N;MFCD00218591;AKOS022661676;2-hydroxy-4-methoxyphenyl benzyl ketone

Chemical Property of 1-(2-Hydroxy-4-methoxyphenyl)-2-phenylethanone

Chemical Property:

• Melting Point: 88–89°C
• PSA: 46.53000
• LogP: 2.82620
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 242.094294304
• Heavy Atom Count: 18
• Complexity: 271

Purity/Quality:

97% ^*data from raw suppliers

1-(2-HYDROXY-4-METHOXYPHENYL)-2-PHENYLETHANONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)C(=O)CC2=CC=CC=C2)O

Technology Process of 1-(2-Hydroxy-4-methoxyphenyl)-2-phenylethanone

There total 25 articles about 1-(2-Hydroxy-4-methoxyphenyl)-2-phenylethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

phenylacetic acid (103-82-2) + O-methylresorcine (150-19-6) → 1-(2-hydroxy-4-methoxyphenyl)-2-phenylethanone (18439-96-8)

Guidance literature:

With boron trifluoride diethyl etherate; at 85 ℃; for 1.5h;

DOI:10.1080/00397910008087343

Reference yield: 90.0%

1-(2,4-dihydroxyphenyl)-2-phenylethanone (3669-41-8) + methyl iodide (74-88-4) → 1-(2-hydroxy-4-methoxyphenyl)-2-phenylethanone (18439-96-8) + 1-(2,4-dimethoxyphenyl)-2-phenylethanone (76246-93-0)

Guidance literature:

With potassium carbonate; In acetone; at 65 ℃; for 4h;

DOI:10.1134/S1070363221120264

Reference yield: 88.0%

methanol (67-56-1) + 1-(2,4-dihydroxyphenyl)-2-phenylethanone (3669-41-8) → 1-(2-hydroxy-4-methoxyphenyl)-2-phenylethanone (18439-96-8)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 0.0833333h;

DOI:10.1016/S0040-4039(02)01342-4

upstream raw materials:

3-(2,4-dimethoxy-phenyl)-3-oxo-2-phenyl-propionitrile

3-(2,4-dimethoxy-phenyl)-3-oxo-2-phenyl-propionic acid ethyl ester

1-(2,4-dihydroxyphenyl)-2-phenylethanone

dimethyl sulfate

Downstream raw materials:

7-methoxyisoflavanone

4,4'-dimethoxy-2,2'-dibenziloxymethane

1-(2,4-dihydroxyphenyl)-2-phenylethanone

4-acetoxy-7-methoxy-3-phenyl-coumarin

Refernces

• 1、 Li, Chenyu,Liang, Yong,Ma, Zhishuang,Wang, Ding,Wang, Nana,Wang, Tao,Zhang, Zunting. "Synthesis of 7-hydroxy-6H-naphtho[2,3-c]coumarinviaa TsOH-mediated tandem reaction". supporting information. p. 10369 - 10372. Retrieved 2020/09/16.
• 2、 Kumar, Vijayendra,Kumar, Rajesh,Raunak,Poonam,Sharma, Sunil K,Prasad, Ashok K,Cholli, Ashok L,Olsen, Carl E,Parmar, Virinder S. "Biocatalytic acylation studies on novel 3-aryl-3-hydroxymethyl-2, 3-dihydro-4H-1-benzopyran-4-ones". . p. 1501 - 1510. Retrieved 2008/09/19.