2-diphenylphosphinoylamino-2-phenyloct-3-enoic acid 5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester

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Chemical Name:2-diphenylphosphinoylamino-2-phenyloct-3-enoic acid 5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester
CAS No.:573703-13-6
Molecular Formula:C₄₂H₅₀NO₃P
Molecular Weight:647.838
Hs Code.:

Synonyms:2-diphenylphosphinoylamino-2-phenyloct-3-enoic acid 5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester

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Chemical Property of 2-diphenylphosphinoylamino-2-phenyloct-3-enoic acid 5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester

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Technology Process of 2-diphenylphosphinoylamino-2-phenyloct-3-enoic acid 5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester

There total 4 articles about 2-diphenylphosphinoylamino-2-phenyloct-3-enoic acid 5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 693-02-7
hex-1-yne

: 573703-12-5
(1R,2S,5R)-diphenylphosphinoyliminophenylacetic acid 5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester

: 573703-13-6
2-diphenylphosphinoylamino-2-phenyloct-3-enoic acid 5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester

: 2-diphenylphosphinoylamino-2-phenyloct-3-enoic acid 5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester

Guidance literature:: hex-1-yne; With Schwartz's reagent; In dichloromethane; at 20 ℃; for 0.166667h;

With dimethyl zinc(II); In toluene; at -78 - -40 ℃;

(1R,2S,5R)-diphenylphosphinoyliminophenylacetic acid 5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester; With triisopropoxytitanium(IV) chloride; In dichloromethane; toluene; at -40 ℃; for 24h;
DOI:10.1021/ol0347141

Reference yield:

: 25726-04-9
phenylglyoxylyl chloride

: 573703-13-6
2-diphenylphosphinoylamino-2-phenyloct-3-enoic acid 5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 91 percent / DMAP; pyridine / CH₂Cl₂ / 0 °C

2.1: 69 percent / TiCl₄; Et₃N / CH₂Cl₂ / 36 h / 20 °C

3.1: Cp₂Zr(H)Cl / CH₂Cl₂ / 0.17 h / 20 °C

3.2: Me₂Zn / toluene / -78 - -40 °C

3.3: TiCl(O-i-Pr)3 / toluene; CH₂Cl₂ / 24 h / -40 °C

With pyridine; dmap; Schwartz's reagent; titanium tetrachloride; triethylamine; In dichloromethane;
DOI:10.1021/ol0347141

Reference yield:

: 88002-15-7
Phenylglyoxylsaeure-<(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)-1-cyclohexyl>ester

: 573703-13-6
2-diphenylphosphinoylamino-2-phenyloct-3-enoic acid 5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 69 percent / TiCl₄; Et₃N / CH₂Cl₂ / 36 h / 20 °C

2.1: Cp₂Zr(H)Cl / CH₂Cl₂ / 0.17 h / 20 °C

2.2: Me₂Zn / toluene / -78 - -40 °C

2.3: TiCl(O-i-Pr)3 / toluene; CH₂Cl₂ / 24 h / -40 °C

With Schwartz's reagent; titanium tetrachloride; triethylamine; In dichloromethane;
DOI:10.1021/ol0347141