3,5-difluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)benzaldehyde

Base Information

• Chemical Name: 3,5-difluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)benzaldehyde
• CAS No.: 1620579-54-5
• Molecular Formula: C₁₃H₆F₅NO₂
• Molecular Weight: 303.188
• Mol file: 1620579-54-5.mol

Synonyms:3,5-difluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)benzaldehyde

Chemical Property of 3,5-difluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)benzaldehyde

Chemical Property:

• Boiling Point: 288.8±40.0 °C(Predicted)
• PKA: -0.12±0.20(Predicted)
• Density: 1.465±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-difluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)benzaldehyde

There total 3 articles about 3,5-difluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-hydroxy-2-trifluoromethylpyridine (170886-13-2) + 3,4,5-trifluorobenzaldehyde (132123-54-7) → 3,5-difluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)benzaldehyde (1620579-54-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 16h; Temperature; Time; Inert atmosphere;

Reference yield:

2-(trifluoromethyl)-4H-pyran-4-one (204516-31-4) → 3,5-difluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)benzaldehyde (1620579-54-5)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium hydroxide / methanol / 10 h / 25 - 90 °C

2: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere

With ammonium hydroxide; potassium carbonate; In methanol; N,N-dimethyl-formamide;

Reference yield:

→ 3,5-difluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)benzaldehyde (1620579-54-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 110 ℃; for 12h;

upstream raw materials:

4-hydroxy-2-trifluoromethylpyridine

3,4,5-trifluorobenzaldehyde

2-(trifluoromethyl)-4H-pyran-4-one

Downstream raw materials:

(3,5-difluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)phenyl)methanol

(S)-7-((3,5-difluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)benzyl)oxy)-1,2-dimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

(S)-7-((3,5-difluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)benzyl)oxy)-2-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

(R)-7-((3,5-difluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)benzyl)oxy)-2-methyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one