4-(tert-butylthio)phenyl methyl sulfone

Base Information

• Chemical Name: 4-(tert-butylthio)phenyl methyl sulfone
• CAS No.: 1393937-27-3
• Molecular Formula: C₁₁H₁₆O₂S₂
• Molecular Weight: 244.379
• Mol file: 1393937-27-3.mol

Synonyms:4-(tert-butylthio)phenyl methyl sulfone

Chemical Property of 4-(tert-butylthio)phenyl methyl sulfone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(tert-butylthio)phenyl methyl sulfone

There total 1 articles about 4-(tert-butylthio)phenyl methyl sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

sodium tert-butyl thiolate (29364-29-2) + 4-chlorophenyl methyl sulfone (98-57-7) → 4-(tert-butylthio)phenyl methyl sulfone (1393937-27-3)

Guidance literature:

With 1-methyl-pyrrolidin-2-one; at 5 ℃; Inert atmosphere;

DOI:10.3762/bjoc.8.53

Reference yield: 91.0%

4-(tert-butylthio)phenyl methyl sulfone (1393937-27-3) → 4-(methylsulfonyl)benzenethiol (3814-25-3)

Guidance literature:

4-(tert-butylthio)phenyl methyl sulfone; With aluminum (III) chloride; In toluene; at 20 ℃; for 4h; Inert atmosphere;

With hydrogenchloride; water; In diethyl ether; toluene;

DOI:10.3762/bjoc.8.53

Reference yield:

4-(tert-butylthio)phenyl methyl sulfone (1393937-27-3) → p-(methanesulfonyl)phenyl chlorotetrafluoride (1393937-26-2)

Guidance literature:

Multi-step reaction with 3 steps

1: aluminum (III) chloride / toluene / 4 h / 20 °C / Inert atmosphere

2: bromine; acetic acid / n-heptane; dichloromethane / 3 h

3: potassium fluoride; chlorine / acetonitrile / 20 °C / Cooling with ice; Inert atmosphere

With aluminum (III) chloride; potassium fluoride; bromine; chlorine; acetic acid; In n-heptane; dichloromethane; toluene; acetonitrile;

DOI:10.3762/bjoc.8.53

upstream raw materials:

sodium tert-butyl thiolate

4-chlorophenyl methyl sulfone

Downstream raw materials:

p-(methanesulfonyl)phenyl chlorotetrafluoride

4-(methylsulfonyl)benzenethiol

bis[4-(methanesulfonyl)phenyl] disulfide

Refernces