(R)-2-hydroxy-4-oxo-4-phenylbutanoic acid

Base Information

Chemical Name:(R)-2-hydroxy-4-oxo-4-phenylbutanoic acid
CAS No.:146912-66-5
Molecular Formula:C₁₀H₁₀O₄
Molecular Weight:194.187
Hs Code.:

Synonyms:(R)-2-hydroxy-4-oxo-4-phenylbutanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-hydroxy-4-oxo-4-phenylbutanoic acid

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Technology Process of (R)-2-hydroxy-4-oxo-4-phenylbutanoic acid

There total 10 articles about (R)-2-hydroxy-4-oxo-4-phenylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 6296-54-4
ethyl 2,4-dioxo-4-phenylbutyrate

: 146912-66-5
(R)-2-hydroxy-4-oxo-4-phenylbutanoic acid

Guidance literature:: With sodium formate; 1,1'-dibenzyl-4,4'-bipyridinium; In water; at 35 ℃; Product distribution; Mechanism; other ethyl 2,4-dioxoacylates, biosynthesis by Proteus vulgaris (potassium phosphate buffer pH 7.0, with concomitant hydrolysis by Lipozyme^R);
DOI:10.1016/S0040-4020(01)86506-6

Reference yield: 80.0%

: 6296-54-4
ethyl 2,4-dioxo-4-phenylbutyrate

: 5650-41-9
3-hydroxy-1-phenylpropan-1-one

: 146912-66-5
(R)-2-hydroxy-4-oxo-4-phenylbutanoic acid

: 244277-48-3
ethyl (R)-(-)-2-hydroxy-4-oxo-4-phenylbutanoate

Guidance literature:: With Saccharomyces cerevisiae cells; 1-chloroacetophenone; In di-isopropyl ether; water; at 20 ℃; for 48h; pH=4.5;
DOI:10.1016/j.tetasy.2004.09.007

Reference yield: 74.0%

: 159974-68-2
(R)-3,4-dihydroxy-1-phenylbutan-1-one

: 146912-66-5
(R)-2-hydroxy-4-oxo-4-phenylbutanoic acid

Guidance literature:: With sodium hypochlorite; sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In aq. phosphate buffer; toluene; at 25 ℃; for 11h; pH=6.8;
DOI:10.1016/j.tet.2017.03.076