(S)-2-(((tert-butyldimethylsilyl)oxy)diphenylmethyl)-5-methoxy-3,4-dihydro-2H-pyrrole

Base Information

Chemical Name:(S)-2-(((tert-butyldimethylsilyl)oxy)diphenylmethyl)-5-methoxy-3,4-dihydro-2H-pyrrole
CAS No.:1447813-88-8
Molecular Formula:C₂₄H₃₃NO₂Si
Molecular Weight:395.617
Hs Code.:

Synonyms:(S)-2-(((tert-butyldimethylsilyl)oxy)diphenylmethyl)-5-methoxy-3,4-dihydro-2H-pyrrole

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Chemical Property of (S)-2-(((tert-butyldimethylsilyl)oxy)diphenylmethyl)-5-methoxy-3,4-dihydro-2H-pyrrole

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Technology Process of (S)-2-(((tert-butyldimethylsilyl)oxy)diphenylmethyl)-5-methoxy-3,4-dihydro-2H-pyrrole

There total 5 articles about (S)-2-(((tert-butyldimethylsilyl)oxy)diphenylmethyl)-5-methoxy-3,4-dihydro-2H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 420-37-1
trimethoxonium tetrafluoroborate

: 249617-46-7
(-)-(S)-[Diphenyl(tert-butyldimethylsilyloxy)methyl]pyrrolidin-2-one

: 1447813-88-8
(S)-2-(((tert-butyldimethylsilyl)oxy)diphenylmethyl)-5-methoxy-3,4-dihydro-2H-pyrrole

Guidance literature:: In dichloromethane; at 10 ℃; for 15h;
DOI:10.2533/CHIMIA.2020.878

Reference yield:

: 149561-81-9
(-)-(S)-5-(Hydroxydiphenylmethyl)pyrrolidin-2-one

: 1447813-88-8
(S)-2-(((tert-butyldimethylsilyl)oxy)diphenylmethyl)-5-methoxy-3,4-dihydro-2H-pyrrole

Guidance literature:: Multi-step reaction with 2 steps

1: 2,6-dimethylpyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

2: dichloromethane / 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; In dichloromethane;
DOI:10.1002/chem.201202432

Reference yield:

: 98-79-3
L-Pyroglutamic acid

: 1447813-88-8
(S)-2-(((tert-butyldimethylsilyl)oxy)diphenylmethyl)-5-methoxy-3,4-dihydro-2H-pyrrole

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / 0 - 20 °C / Inert atmosphere

2.1: magnesium; iodine / tetrahydrofuran / 4 h / Inert atmosphere; Reflux

2.2: 0 - 20 °C / Inert atmosphere

3.1: 2,6-dimethylpyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

4.1: dichloromethane / 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; thionyl chloride; iodine; magnesium; In tetrahydrofuran; dichloromethane;
DOI:10.1002/chem.201202432