Technology Process of ethyl [2-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yloxy)]-2-phenylacetate
There total 8 articles about ethyl [2-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yloxy)]-2-phenylacetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
at 0 ℃;
Inert atmosphere;
DOI:10.1021/jm101225g
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: toluene-4-sulfonic acid / toluene / 4 h / Reflux
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 4 h / 65 °C / Cooling; Inert atmosphere
3.1: n-butyllithium; Triisopropyl borate / tetrahydrofuran / -80 - 20 °C / Inert atmosphere
3.2: 2 h
4.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 °C
5.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C
6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C / Inert atmosphere
With
sodium tetrahydroborate; n-butyllithium; Triisopropyl borate; palladium 10% on activated carbon; hydrogen; sodium hydride; toluene-4-sulfonic acid;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1021/jm101225g
- Guidance literature:
-
Multi-step reaction with 2 steps
1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C
2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C / Inert atmosphere
With
palladium 10% on activated carbon; hydrogen; sodium hydride;
In
methanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm101225g
