Diphenyl-phosphinic acid 1-[(3S,8R,9S,10R,13S,14S)-3-(tert-butyl-dimethyl-silanyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2,2-difluoro-1-methyl-ethyl ester

Base Information

Chemical Name:Diphenyl-phosphinic acid 1-[(3S,8R,9S,10R,13S,14S)-3-(tert-butyl-dimethyl-silanyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2,2-difluoro-1-methyl-ethyl ester
CAS No.:512779-34-9
Molecular Formula:C₄₀H₅₅F₂O₃PSi
Molecular Weight:680.931
Hs Code.:

Diphenyl-phosphinic acid 1-[(3S,8R,9S,10R,13S,14S)-3-(tert-butyl-dimethyl-silanyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2,2-difluoro-1-methyl-ethyl ester

Synonyms:Diphenyl-phosphinic acid 1-[(3S,8R,9S,10R,13S,14S)-3-(tert-butyl-dimethyl-silanyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2,2-difluoro-1-methyl-ethyl ester

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Chemical Property of Diphenyl-phosphinic acid 1-[(3S,8R,9S,10R,13S,14S)-3-(tert-butyl-dimethyl-silanyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2,2-difluoro-1-methyl-ethyl ester

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Technology Process of Diphenyl-phosphinic acid 1-[(3S,8R,9S,10R,13S,14S)-3-(tert-butyl-dimethyl-silanyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2,2-difluoro-1-methyl-ethyl ester

There total 3 articles about Diphenyl-phosphinic acid 1-[(3S,8R,9S,10R,13S,14S)-3-(tert-butyl-dimethyl-silanyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2,2-difluoro-1-methyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.7%

: 129932-29-2
difluoromethyl-diphenyl-phosphine oxide

: 58701-41-0
3β-(tert-butyldimethylsilyloxy)pregna-5,16-dien-20-one

: 512779-34-9
Diphenyl-phosphinic acid 1-[(3S,8R,9S,10R,13S,14S)-3-(tert-butyl-dimethyl-silanyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2,2-difluoro-1-methyl-ethyl ester

Guidance literature:: difluoromethyl-diphenyl-phosphine oxide; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h;

3β-(tert-butyldimethylsilyloxy)pregna-5,16-dien-20-one; In tetrahydrofuran; for 2h; Heating;
DOI:10.1016/S0968-0896(02)00434-0

Reference yield:

: 1162-53-4
16-dehydropregnenolone

: 512779-34-9
Diphenyl-phosphinic acid 1-[(3S,8R,9S,10R,13S,14S)-3-(tert-butyl-dimethyl-silanyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2,2-difluoro-1-methyl-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 80.5 percent / dimethylaminopyridine / pyridine / 72 h

2.1: LDA / tetrahydrofuran / 1 h / -78 °C

2.2: 19.7 percent / tetrahydrofuran / 2 h / Heating

With dmap; lithium diisopropyl amide; In tetrahydrofuran; pyridine;
DOI:10.1016/S0968-0896(02)00434-0

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 512779-34-9
Diphenyl-phosphinic acid 1-[(3S,8R,9S,10R,13S,14S)-3-(tert-butyl-dimethyl-silanyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2,2-difluoro-1-methyl-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 80.5 percent / dimethylaminopyridine / pyridine / 72 h

2.1: LDA / tetrahydrofuran / 1 h / -78 °C

2.2: 19.7 percent / tetrahydrofuran / 2 h / Heating

With dmap; lithium diisopropyl amide; In tetrahydrofuran; pyridine;
DOI:10.1016/S0968-0896(02)00434-0