Difluoromethyldiphenylphosphine oxide

Base Information

Chemical Name:Difluoromethyldiphenylphosphine oxide
CAS No.:129932-29-2
Molecular Formula:C13H11F2OP
Molecular Weight:252.2
Hs Code.:
DSSTox Substance ID:DTXSID50576088
Wikidata:Q82465619

Synonyms:DIFLUOROMETHYLDIPHENYLPHOSPHINE OXIDE;129932-29-2;[difluoromethyl(phenyl)phosphoryl]benzene;Phosphine oxide, (difluoromethyl)diphenyl-;SCHEMBL581800;DTXSID50576088;(Difluoromethyl)diphenylphosphinoxid;difluoromethyldi-phenylphosphine oxide;difluoromethyl-diphenyl-phosphine-oxide;(difluoromethyl-phenylphosphoryl)benzene;(difluoromethyl)(diphenyl)phosphine oxide;(Difluoromethyl)(oxo)diphenyl-lambda~5~-phosphane

Suppliers and Price of Difluoromethyldiphenylphosphine oxide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of Difluoromethyldiphenylphosphine oxide

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:252.05155829
Heavy Atom Count:17
Complexity:259

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)P(=O)(C2=CC=CC=C2)C(F)F

Technology Process of Difluoromethyldiphenylphosphine oxide

There total 3 articles about Difluoromethyldiphenylphosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4559-70-0
Diphenylphosphine oxide

: 129932-29-2
difluoromethyl-diphenyl-phosphine oxide

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; dichloromethane; chloroform; water;

Reference yield:

: 81290-20-2
(trifluoromethyl)trimethylsilane

: 4559-70-0
Diphenylphosphine oxide

: C₁₆H₁₉F₂OPSi

: 129932-29-2
difluoromethyl-diphenyl-phosphine oxide

Guidance literature:: Diphenylphosphine oxide; With lithium hydride; lithium chloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere; Sealed tube; Glovebox;

(trifluoromethyl)trimethylsilane; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h; Inert atmosphere; Sealed tube; Glovebox;
DOI:10.1021/acs.orglett.9b00381

Reference yield:

: 75-45-6
Chlorodifluoromethane

: 4559-70-0
Diphenylphosphine oxide

: 129932-29-2
difluoromethyl-diphenyl-phosphine oxide

Guidance literature:: With n-butyllithium; Yield given. Multistep reaction; 1) THF, hexane, -50 deg C, 15 min, 2) -50 deg C, 4 h, then rt, 18 h;
DOI:10.1016/S0040-4039(00)97899-7