4-(trifluoromethyl)phenyl 4-fluorobenzyl ketone

Base Information

Chemical Name:4-(trifluoromethyl)phenyl 4-fluorobenzyl ketone
CAS No.:146652-97-3
Molecular Formula:C₁₅H₁₀F₄O
Molecular Weight:282.237
Hs Code.:

Synonyms:4-(trifluoromethyl)phenyl 4-fluorobenzyl ketone

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Chemical Property of 4-(trifluoromethyl)phenyl 4-fluorobenzyl ketone

Chemical Property:

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Technology Process of 4-(trifluoromethyl)phenyl 4-fluorobenzyl ketone

There total 1 articles about 4-(trifluoromethyl)phenyl 4-fluorobenzyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 455-18-5
4-CF₃C₆H₄CN

: 352-11-4
1-chloromethyl-4-fluorobenzene

: 146652-97-3
4-(trifluoromethyl)phenyl 4-fluorobenzyl ketone

Guidance literature:: With magnesium; In diethyl ether; for 3h; Reflux;
DOI:10.1002/ejoc.201300976

Reference yield: 94.0%

: 146652-97-3
4-(trifluoromethyl)phenyl 4-fluorobenzyl ketone

: 35923-46-7
1-(4-fluoro-phenyl)-2-(4-trifluoromethyl-phenyl)-ethane-1,2-dione

Guidance literature:: With selenium(IV) oxide; In acetic acid; for 3h; Reflux;
DOI:10.1002/ejoc.201300976

Reference yield:

: 146652-97-3
4-(trifluoromethyl)phenyl 4-fluorobenzyl ketone

: N-(4-fluorobenzyl)-N'-[4-(trifluoromethyl)benzyl]benzamidine

Guidance literature:: Multi-step reaction with 3 steps

1: selenium(IV) oxide / acetic acid / 3 h / Reflux

2: ammonium acetate / acetic acid / Reflux; Inert atmosphere

3: methylene blue; oxygen / dichloromethane; methanol / 1.5 h / -78 °C

With selenium(IV) oxide; ammonium acetate; oxygen; methylene blue; In methanol; dichloromethane; acetic acid;
DOI:10.1002/ejoc.201300976