5-(4-fluorophenyl)-2-phenyl-4-[4-(trifluoromethyl)phenyl]imidazole

Base Information

• Chemical Name: 5-(4-fluorophenyl)-2-phenyl-4-[4-(trifluoromethyl)phenyl]imidazole
• CAS No.: 1594937-22-0
• Molecular Formula: C₂₂H₁₄F₄N₂
• Molecular Weight: 382.36
• Mol file: 1594937-22-0.mol

Synonyms:5-(4-fluorophenyl)-2-phenyl-4-[4-(trifluoromethyl)phenyl]imidazole

Chemical Property of 5-(4-fluorophenyl)-2-phenyl-4-[4-(trifluoromethyl)phenyl]imidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 5-(4-fluorophenyl)-2-phenyl-4-[4-(trifluoromethyl)phenyl]imidazole

There total 6 articles about 5-(4-fluorophenyl)-2-phenyl-4-[4-(trifluoromethyl)phenyl]imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

1-(4-fluoro-phenyl)-2-(4-trifluoromethyl-phenyl)-ethane-1,2-dione (35923-46-7) + benzaldehyde (100-52-7) → 5-(4-fluorophenyl)-2-phenyl-4-[4-(trifluoromethyl)phenyl]imidazole (1594937-22-0)

Guidance literature:

With ammonium acetate; In acetic acid; Reflux; Inert atmosphere;

DOI:10.1002/ejoc.201300976

Reference yield: 17.0%

(R)-2-phenyl-4-(p-trifluoromethyl-phenyl)-5-(p-fluoro-phenyl)-4-tert-butyldimethylsilylperoxy-4H-isoimidazole → 5-(4-fluorophenyl)-2-phenyl-4-[4-(trifluoromethyl)phenyl]imidazole (1594937-22-0) + N-(4-fluorobenzyl)-N'-[4-(trifluoromethyl)benzyl]benzamidine

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; chloroform;

DOI:10.1002/ejoc.201300976

Reference yield: 14.0%

4-(tert-butyldimethylsilylperoxy)-4-(4-fluorophenyl)-2-phenyl-5-[4-(trifluoromethyl)phenyl]-4H-isoimidazole (1594937-33-3) → 5-(4-fluorophenyl)-2-phenyl-4-[4-(trifluoromethyl)phenyl]imidazole (1594937-22-0) + N-(4-fluorobenzyl)-N'-[4-(trifluoromethyl)benzyl]benzamidine

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; chloroform;

DOI:10.1002/ejoc.201300976

upstream raw materials:

4-CF₃C₆H₄CN

1-chloromethyl-4-fluorobenzene

4-(trifluoromethyl)phenyl 4-fluorobenzyl ketone

1-(4-fluoro-phenyl)-2-(4-trifluoromethyl-phenyl)-ethane-1,2-dione

Downstream raw materials:

4-(tert-butyldimethylsilylperoxy)-4-(4-fluorophenyl)-2-phenyl-5-[4-(trifluoromethyl)phenyl]-4H-isoimidazole