4-(tert-butyldimethylsilylperoxy)-4-(4-fluorophenyl)-2-phenyl-5-[4-(trifluoromethyl)phenyl]-4H-isoimidazole

Base Information

Chemical Name:4-(tert-butyldimethylsilylperoxy)-4-(4-fluorophenyl)-2-phenyl-5-[4-(trifluoromethyl)phenyl]-4H-isoimidazole
CAS No.:1594937-33-3
Molecular Formula:C₂₈H₂₈F₄N₂O₂Si
Molecular Weight:528.622
Hs Code.:

Synonyms:4-(tert-butyldimethylsilylperoxy)-4-(4-fluorophenyl)-2-phenyl-5-[4-(trifluoromethyl)phenyl]-4H-isoimidazole

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Chemical Property of 4-(tert-butyldimethylsilylperoxy)-4-(4-fluorophenyl)-2-phenyl-5-[4-(trifluoromethyl)phenyl]-4H-isoimidazole

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Technology Process of 4-(tert-butyldimethylsilylperoxy)-4-(4-fluorophenyl)-2-phenyl-5-[4-(trifluoromethyl)phenyl]-4H-isoimidazole

There total 5 articles about 4-(tert-butyldimethylsilylperoxy)-4-(4-fluorophenyl)-2-phenyl-5-[4-(trifluoromethyl)phenyl]-4H-isoimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1594937-22-0
5-(4-fluorophenyl)-2-phenyl-4-[4-(trifluoromethyl)phenyl]imidazole

: 18162-48-6
tert-butyldimethylsilyl chloride

: (R)-2-phenyl-4-(p-trifluoromethyl-phenyl)-5-(p-fluoro-phenyl)-4-tert-butyldimethylsilylperoxy-4H-isoimidazole

: 1594937-33-3
4-(tert-butyldimethylsilylperoxy)-4-(4-fluorophenyl)-2-phenyl-5-[4-(trifluoromethyl)phenyl]-4H-isoimidazole

Guidance literature:: 5-(4-fluorophenyl)-2-phenyl-4-[4-(trifluoromethyl)phenyl]imidazole; With oxygen; methylene blue; In methanol; dichloromethane; at -78 ℃; for 1.5h;

tert-butyldimethylsilyl chloride; With 1H-imidazole; In pyridine; at 0 ℃; for 0.333333h;

In hexane; isopropyl alcohol;
DOI:10.1002/ejoc.201300976

Reference yield:

: 352-11-4
1-chloromethyl-4-fluorobenzene

: 1594937-33-3
4-(tert-butyldimethylsilylperoxy)-4-(4-fluorophenyl)-2-phenyl-5-[4-(trifluoromethyl)phenyl]-4H-isoimidazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: magnesium / diethyl ether / 3 h / Reflux

2.1: selenium(IV) oxide / acetic acid / 3 h / Reflux

3.1: ammonium acetate / acetic acid / Reflux; Inert atmosphere

4.1: methylene blue; oxygen / dichloromethane; methanol / 1.5 h / -78 °C

4.2: 0.33 h / 0 °C

4.3: Daicel Chiralpak AD-H column

With selenium(IV) oxide; ammonium acetate; oxygen; methylene blue; magnesium; In methanol; diethyl ether; dichloromethane; acetic acid;
DOI:10.1002/ejoc.201300976

Reference yield:

: 146652-97-3
4-(trifluoromethyl)phenyl 4-fluorobenzyl ketone

: 1594937-33-3
4-(tert-butyldimethylsilylperoxy)-4-(4-fluorophenyl)-2-phenyl-5-[4-(trifluoromethyl)phenyl]-4H-isoimidazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: selenium(IV) oxide / acetic acid / 3 h / Reflux

2.1: ammonium acetate / acetic acid / Reflux; Inert atmosphere

3.1: methylene blue; oxygen / dichloromethane; methanol / 1.5 h / -78 °C

3.2: 0.33 h / 0 °C

3.3: Daicel Chiralpak AD-H column

With selenium(IV) oxide; ammonium acetate; oxygen; methylene blue; In methanol; dichloromethane; acetic acid;
DOI:10.1002/ejoc.201300976