3(2H)-Benzofuranone, 2-hydroxy-

Base Information

• Chemical Name: 3(2H)-Benzofuranone, 2-hydroxy-
• CAS No.: 17392-15-3
• Molecular Formula: C8H6 O3
• Molecular Weight: 150.134
• Hs Code.: 2932999099
• Mol file: 17392-15-3.mol

Synonyms:2-Hydroxy-3(2H)-benzofuranone;2-Hydroxy-3-coumaranone; 2-Hydroxycoumaranone

Chemical Property of 3(2H)-Benzofuranone, 2-hydroxy-

Chemical Property:

• Melting Point: 108.5-110 °C(Solv: ethyl ether (60-29-7))
• Boiling Point: 327.8±42.0 °C(Predicted)
• PKA: 10.38±0.20(Predicted)
• PSA: 46.53000
• Density: 1.456±0.06 g/cm3(Predicted)
• LogP: 0.58010

Purity/Quality:

99% ^*data from raw suppliers

2-hydroxy-3(2H)-Benzofuranone 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3(2H)-Benzofuranone, 2-hydroxy-

There total 7 articles about 3(2H)-Benzofuranone, 2-hydroxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

benzofurane-3-ylboronic acid → 2-hydroxy-3(2H)-benzofuranone (17392-15-3)

Guidance literature:

With O₅V₂⁽¹⁰⁾,O₂Ti(b) (W%); water; dihydrogen peroxide; In acetonitrile; at 25 ℃; Green chemistry;

DOI:10.1002/ejoc.202100614

Reference yield: 72.0%

o-hydroxyacetophenone (118-93-4,104809-67-8) → 2-hydroxy-3(2H)-benzofuranone (17392-15-3)

Guidance literature:

With iodine; 1,8-diazabicyclo[5.4.0]undec-7-ene; copper(II) oxide; In dimethyl sulfoxide; at 100 ℃; for 2h; Sealed tube;

DOI:10.1016/j.tet.2014.05.015

Reference yield: 12.0%

1-benzofurane (271-89-6) → benzofuran-2(3H)-one (553-86-6) + 2-hydroxy-3(2H)-benzofuranone (17392-15-3) + salicylaldehyde (90-02-8)

Guidance literature:

With molybdenum peroxide hexamethylphosphorylamide; In dichloromethane; for 168h; Ambient temperature;

upstream raw materials:

1-benzofurane

diethyl ether

salicylaldehyde

hydrogenchloride

Downstream raw materials:

2-hydroxy-1-(2-hydroxyphenyl)ethanone

2-Hydroxybenzoylmethyl-2-hydroxyphenylglyoxylat

(2-hydroxyphenyl)oxoacetic acid

2,3-Dihydroxy-1,4-bis-(2-hydroxy-phenyl)-butandion-(1,4)