(4-fluoro-benzyl)-(5-hydroxy-6-hydroxycarbamoyl-4-methyl-pyridin-3-ylmethyl)-carbamic acid benzyl ester

Base Information

Chemical Name:(4-fluoro-benzyl)-(5-hydroxy-6-hydroxycarbamoyl-4-methyl-pyridin-3-ylmethyl)-carbamic acid benzyl ester
CAS No.:1198621-00-9
Molecular Formula:C₂₃H₂₂FN₃O₅
Molecular Weight:439.443
Hs Code.:

Synonyms:(4-fluoro-benzyl)-(5-hydroxy-6-hydroxycarbamoyl-4-methyl-pyridin-3-ylmethyl)-carbamic acid benzyl ester

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Chemical Property of (4-fluoro-benzyl)-(5-hydroxy-6-hydroxycarbamoyl-4-methyl-pyridin-3-ylmethyl)-carbamic acid benzyl ester

Chemical Property:

Purity/Quality:

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Technology Process of (4-fluoro-benzyl)-(5-hydroxy-6-hydroxycarbamoyl-4-methyl-pyridin-3-ylmethyl)-carbamic acid benzyl ester

There total 10 articles about (4-fluoro-benzyl)-(5-hydroxy-6-hydroxycarbamoyl-4-methyl-pyridin-3-ylmethyl)-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₄H₂₃FN₂O₅

: 1198621-00-9
(4-fluoro-benzyl)-(5-hydroxy-6-hydroxycarbamoyl-4-methyl-pyridin-3-ylmethyl)-carbamic acid benzyl ester

Guidance literature:: With hydroxylamine; In tetrahydrofuran; water; at 60 ℃; for 1h;

Reference yield:

: 1198621-14-5
methyl 5-((4-methoxybenzyloxy)methyl)-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine-8-carboxylate

: 1198621-00-9
(4-fluoro-benzyl)-(5-hydroxy-6-hydroxycarbamoyl-4-methyl-pyridin-3-ylmethyl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: formic acid / 1 h / 20 °C

2: triethylamine / dmap / dichloromethane / 3 h

3: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 3 h

4: trifluoroacetic acid / tripropylsilane / dichloromethane

5: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 3 h / Reflux

6: sodium cyanoborohydride / methanol / 2 h

7: triethylamine / dichloromethane

8: hydroxylamine / tetrahydrofuran; water / 1 h / 60 °C

With formic acid; hydrogen; hydroxylamine; sodium cyanoborohydride; triethylamine; trifluoroacetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; dmap; tripropylsilane; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate;

Reference yield:

: 5-(4-methoxybenzyloxymethyl)-3-hydroxy-4-methylpyridine-2-carboxylic acid methyl ester

: 1198621-00-9
(4-fluoro-benzyl)-(5-hydroxy-6-hydroxycarbamoyl-4-methyl-pyridin-3-ylmethyl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: trifluoroacetic acid / tripropylsilane / dichloromethane

2: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 3 h / Reflux

3: sodium cyanoborohydride / methanol / 2 h

4: triethylamine / dichloromethane

5: hydroxylamine / tetrahydrofuran; water / 1 h / 60 °C

With hydroxylamine; sodium cyanoborohydride; triethylamine; trifluoroacetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; tripropylsilane; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate;