5-[(4-fluoro-benzylamino)-methyl]-3-hydroxy-4-methyl-pyridine-2-carboxylic acid methyl ester

Base Information

Chemical Name:5-[(4-fluoro-benzylamino)-methyl]-3-hydroxy-4-methyl-pyridine-2-carboxylic acid methyl ester
CAS No.:1198621-76-9
Molecular Formula:C₁₆H₁₇FN₂O₃
Molecular Weight:304.321
Hs Code.:

Synonyms:5-[(4-fluoro-benzylamino)-methyl]-3-hydroxy-4-methyl-pyridine-2-carboxylic acid methyl ester

Suppliers and Price of 5-[(4-fluoro-benzylamino)-methyl]-3-hydroxy-4-methyl-pyridine-2-carboxylic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Methyl5-(((4-fluorobenzyl)amino)methyl)-3-hydroxy-4-methylpicolinate 95+%
1g
$ 880.00

Chemenu
methyl5-(((4-fluorobenzyl)amino)methyl)-3-hydroxy-4-methylpicolinate 95%
1g
$ 830.00

Alichem
Methyl5-(((4-fluorobenzyl)amino)methyl)-3-hydroxy-4-methylpicolinate
1g
$ 998.00

Total 2 raw suppliers

Chemical Property of 5-[(4-fluoro-benzylamino)-methyl]-3-hydroxy-4-methyl-pyridine-2-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

95+% ^*data from raw suppliers

Methyl5-(((4-fluorobenzyl)amino)methyl)-3-hydroxy-4-methylpicolinate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-[(4-fluoro-benzylamino)-methyl]-3-hydroxy-4-methyl-pyridine-2-carboxylic acid methyl ester

There total 8 articles about 5-[(4-fluoro-benzylamino)-methyl]-3-hydroxy-4-methyl-pyridine-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₉H₉NO₄

: 140-75-0
para-fluorobenzylamine

: 1198621-76-9
5-[(4-fluoro-benzylamino)-methyl]-3-hydroxy-4-methyl-pyridine-2-carboxylic acid methyl ester

Guidance literature:: With sodium cyanoborohydride; In methanol; for 2h;

Reference yield:

: 1198621-15-6
methyl 3-hydroxy-4-(hydroxymethyl)-5-((4-methoxybenzyloxy)methyl)picolinate

: 1198621-76-9
5-[(4-fluoro-benzylamino)-methyl]-3-hydroxy-4-methyl-pyridine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dmap / dichloromethane / 3 h

2: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 3 h

3: trifluoroacetic acid / tripropylsilane / dichloromethane

4: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 3 h / Reflux

5: sodium cyanoborohydride / methanol / 2 h

With hydrogen; sodium cyanoborohydride; triethylamine; trifluoroacetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; dmap; tripropylsilane; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;

Reference yield:

: 5-(4-methoxybenzyloxymethyl)-3-hydroxy-4-methylpyridine-2-carboxylic acid methyl ester

: 1198621-76-9
5-[(4-fluoro-benzylamino)-methyl]-3-hydroxy-4-methyl-pyridine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / tripropylsilane / dichloromethane

2: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 3 h / Reflux

3: sodium cyanoborohydride / methanol / 2 h

With sodium cyanoborohydride; trifluoroacetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; tripropylsilane; In methanol; dichloromethane; ethyl acetate;