Technology Process of (3R,3aS,7S,7aR)-3-Benzyloxymethyl-7,7a-dimethyl-hexahydro-isobenzofuran-1-one
There total 6 articles about (3R,3aS,7S,7aR)-3-Benzyloxymethyl-7,7a-dimethyl-hexahydro-isobenzofuran-1-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(3R,3aS,7S,7aR)-3-Benzyloxymethyl-7-methyl-hexahydro-isobenzofuran-1-one;
With
lithium diisopropyl amide;
In
tetrahydrofuran;
at -78 ℃;
for 1h;
methyl iodide;
In
tetrahydrofuran;
at -78 - -20 ℃;
for 2h;
Further stages.;
DOI:10.1021/ol0067890
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: NaH / tetrahydrofuran; various solvent(s) / 0.5 h / 20 °C
1.2: 82 percent / tetrahydrofuran; various solvent(s) / 3 h
3.1: Bu3SnH; Et3B; Et2AlCl3 / toluene; various solvent(s) / -78 - -20 °C
4.1: LDA; INO 390 / tetrahydrofuran; various solvent(s) / 1 h / -78 °C
4.2: tetrahydrofuran; various solvent(s) / 2 h / -78 - -20 °C
With
triethyl borane; tri-n-butyl-tin hydride; sodium hydride; lithium diisopropyl amide;
In
tetrahydrofuran; toluene;
DOI:10.1021/ol0067890
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: L(+)-DIPT; TBHP; Ti(O-i-Pr)4 / CH2Cl2
2.1: NaH / tetrahydrofuran; various solvent(s) / 0.5 h / 20 °C
2.2: 82 percent / tetrahydrofuran; various solvent(s) / 3 h
4.1: Bu3SnH; Et3B; Et2AlCl3 / toluene; various solvent(s) / -78 - -20 °C
5.1: LDA; INO 390 / tetrahydrofuran; various solvent(s) / 1 h / -78 °C
5.2: tetrahydrofuran; various solvent(s) / 2 h / -78 - -20 °C
With
titanium(IV) isopropylate; tert.-butylhydroperoxide; L-(+)-diisopropyl tartrate; triethyl borane; tri-n-butyl-tin hydride; sodium hydride; lithium diisopropyl amide;
In
tetrahydrofuran; dichloromethane; toluene;
1.1: Katsuki-Sharpless epoxidation;
DOI:10.1021/ol0067890
