Malonic acid, 2-methoxyethyl-, diethyl ester

Base Information

• Chemical Name: Malonic acid, 2-methoxyethyl-, diethyl ester
• CAS No.: 6335-02-0
• Molecular Formula: C10H18O5
• Molecular Weight: 218.25
• NSC Number: 17327
• DSSTox Substance ID: DTXSID40212741
• Nikkaji Number: J1.560.948F
• Wikidata: Q83087933

Synonyms:6335-02-0;1,3-diethyl 2-(2-methoxyethyl)propanedioate;Malonic acid, 2-methoxyethyl-, diethyl ester;Diethyl 2-(2-methoxyethyl)malonate;diethyl 2-(2-methoxyethyl)propanedioate;Propanedioic acid, (2-methoxyethyl)-, diethyl ester;SCHEMBL1748128;DTXSID40212741;NSC17327;NSC 17327;NSC-17327;AKOS017547926;CS-0347792;(2-Methoxyethyl)propanedioic acid diethyl ester;EN300-125187

Chemical Property of Malonic acid, 2-methoxyethyl-, diethyl ester

Chemical Property:

• Vapor Pressure: 0.0063mmHg at 25°C
• Boiling Point: 271.8°Cat760mmHg
• Flash Point: 113.2°C
• Density: 1.052g/cm³
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 9
• Exact Mass: 218.11542367
• Heavy Atom Count: 15
• Complexity: 184

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C(CCOC)C(=O)OCC

Technology Process of Malonic acid, 2-methoxyethyl-, diethyl ester

There total 7 articles about Malonic acid, 2-methoxyethyl-, diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Bromoethyl methyl ether (6482-24-2) + diethyl malonate (105-53-3) → ethyl methoxyethylmalonate (6335-02-0)

Guidance literature:

Multistep reaction; (i) Na, EtOH, (ii) /BRN= 773654/;

Reference yield:

2-methoxy-ethyl p-toluenesulfonyloxy ester (17178-10-8,58320-73-3) + sodium diethylmalonate (996-82-7) → ethyl methoxyethylmalonate (6335-02-0)

Guidance literature:

With ethanol;

DOI:10.1021/ja01161a001

Reference yield:

2-chloroethyl methyl ether (627-42-9) + diethyl malonate (105-53-3) → ethyl methoxyethylmalonate (6335-02-0)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) ether, RT, 3 h, 2.) ether, 0 deg C, 1 h;

upstream raw materials:

2-chloroethyl methyl ether

sodium diethylmalonate

2-methoxy-ethyl p-toluenesulfonyloxy ester

2-Bromoethyl methyl ether

Downstream raw materials:

rac-2-amino-4-methoxybutanoic acid

4-methoxybutyric acid

β-Methoxyethyl-isopropyl-malonsaeurediethylester

(2-Methoxy-ethyl)-propyl-malonsaeure-diethylester

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