4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazole

Base Information

Chemical Name:4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazole
CAS No.:1312008-98-2
Molecular Formula:C₁₈H₁₅ClN₄O₂
Molecular Weight:354.796
Hs Code.:

Synonyms:4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazole

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Chemical Property of 4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazole

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Technology Process of 4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazole

There total 12 articles about 4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312008-84-6
N'-hydroxy-1H-indazole-4-carboximidamide

: 213767-19-2
3-chloro-4-[(1-methylethyl)oxy]benzoyl chloride

: 1312008-98-2
4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazole

Guidance literature:: With tetrabutyl ammonium fluoride; benzotriazol-1-ol; 1,2-dichloro-ethane; triethylamine; In tetrahydrofuran; at 20 - 80 ℃;

Reference yield:

: 1312008-84-6
N-hydroxy-1H-indazole-4-carboximidamide

: 213598-07-3
3-chloro-4-isopropoxy-benzoic acid

: 1312008-98-2
4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazole

Guidance literature:: 3-chloro-4-isopropoxy-benzoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; at 20 ℃; for 0.5h;

N-hydroxy-1H-indazole-4-carboximidamide; In tetrahydrofuran; at 20 ℃;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 80 ℃; for 72h;

Reference yield:

: 1312008-85-7
1,1-dimethylethyl 4-[(hydroxyamino)(imino)methyl]-1H-indazole-1-carboxylate

: 213598-07-3
3-chloro-4-isopropoxy-benzoic acid

: 1312008-98-2
4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazole

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 80 - 120 ℃; for 8h;