(E)-N-(4-chlorobenzyl)-4-(1-(triphenylmethyl)imidazol-4-yl)-1-but-1-enesulfonamide

Base Information

• Chemical Name: (E)-N-(4-chlorobenzyl)-4-(1-(triphenylmethyl)imidazol-4-yl)-1-but-1-enesulfonamide
• CAS No.: 220377-79-7
• Molecular Formula: C₃₃H₃₀ClN₃O₂S
• Molecular Weight: 568.139
• Mol file: 220377-79-7.mol

Synonyms:(E)-N-(4-chlorobenzyl)-4-(1-(triphenylmethyl)imidazol-4-yl)-1-but-1-enesulfonamide

Chemical Property of (E)-N-(4-chlorobenzyl)-4-(1-(triphenylmethyl)imidazol-4-yl)-1-but-1-enesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-N-(4-chlorobenzyl)-4-(1-(triphenylmethyl)imidazol-4-yl)-1-but-1-enesulfonamide

There total 5 articles about (E)-N-(4-chlorobenzyl)-4-(1-(triphenylmethyl)imidazol-4-yl)-1-but-1-enesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl (1-((((4-chlorobenzyl)amino)sulfonyl)methyl)-3-(1-(triphenylmethyl) imidazol-4-yl)propyl) carbonate (220377-77-5) → (E)-N-(4-chlorobenzyl)-4-(1-(triphenylmethyl)imidazol-4-yl)-1-but-1-enesulfonamide (220377-79-7)

Guidance literature:

With caesium carbonate; In methanol; at 20 ℃; for 18h;

DOI:10.1016/S0968-0896(01)00295-4

Reference yield:

N-(4-chloro-benzyl)-methanesulfonamide (42060-30-0) → (E)-N-(4-chlorobenzyl)-4-(1-(triphenylmethyl)imidazol-4-yl)-1-but-1-enesulfonamide (220377-79-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 89 percent / N,N-4-dimethylaminopyridine / CH₂Cl₂ / 0.5 h

2.1: LDA / tetrahydrofuran / 1 h / -78 °C

2.2: tetrahydrofuran / 18 h / -78 - 20 °C

3.1: Cs₂CO₃ / methanol / 18 h / 20 °C

With dmap; caesium carbonate; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/S0968-0896(01)00295-4

Reference yield:

4-chlorobenzylamine (104-86-9) → (E)-N-(4-chlorobenzyl)-4-(1-(triphenylmethyl)imidazol-4-yl)-1-but-1-enesulfonamide (220377-79-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 81 percent / Et₃N / CH₂Cl₂ / 2 h

2.1: 89 percent / N,N-4-dimethylaminopyridine / CH₂Cl₂ / 0.5 h

3.1: LDA / tetrahydrofuran / 1 h / -78 °C

3.2: tetrahydrofuran / 18 h / -78 - 20 °C

4.1: Cs₂CO₃ / methanol / 18 h / 20 °C

With dmap; caesium carbonate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/S0968-0896(01)00295-4

upstream raw materials:

tert-butyl (1-((((4-chlorobenzyl)amino)sulfonyl)methyl)-3-(1-(triphenylmethyl) imidazol-4-yl)propyl) carbonate

N-(4-chloro-benzyl)-methanesulfonamide

4-chlorobenzylamine

N-(tert-butoxycarbonyl)-N-(4-chlorobenzyl)-methanesulfonamide

Downstream raw materials:

(E)-N-(4-chlorobenzyl)-4-(1-(triphenylmethyl)imidazol-4-yl)-1-butanesulfonamide