(E)-N-(4-chlorobenzyl)-4-(1-(triphenylmethyl)imidazol-4-yl)-1-butanesulfonamide

Base Information

• Chemical Name: (E)-N-(4-chlorobenzyl)-4-(1-(triphenylmethyl)imidazol-4-yl)-1-butanesulfonamide
• CAS No.: 220377-81-1
• Molecular Formula: C₃₃H₃₂ClN₃O₂S
• Molecular Weight: 570.155
• Mol file: 220377-81-1.mol

Synonyms:(E)-N-(4-chlorobenzyl)-4-(1-(triphenylmethyl)imidazol-4-yl)-1-butanesulfonamide

Chemical Property of (E)-N-(4-chlorobenzyl)-4-(1-(triphenylmethyl)imidazol-4-yl)-1-butanesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-N-(4-chlorobenzyl)-4-(1-(triphenylmethyl)imidazol-4-yl)-1-butanesulfonamide

There total 6 articles about (E)-N-(4-chlorobenzyl)-4-(1-(triphenylmethyl)imidazol-4-yl)-1-butanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-N-(4-chlorobenzyl)-4-(1-(triphenylmethyl)imidazol-4-yl)-1-but-1-enesulfonamide (220377-79-7) → (E)-N-(4-chlorobenzyl)-4-(1-(triphenylmethyl)imidazol-4-yl)-1-butanesulfonamide (220377-81-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; at 20 ℃; for 18h;

DOI:10.1016/S0968-0896(01)00295-4

Reference yield:

N-(4-chloro-benzyl)-methanesulfonamide (42060-30-0) → (E)-N-(4-chlorobenzyl)-4-(1-(triphenylmethyl)imidazol-4-yl)-1-butanesulfonamide (220377-81-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 89 percent / N,N-4-dimethylaminopyridine / CH₂Cl₂ / 0.5 h

2.1: LDA / tetrahydrofuran / 1 h / -78 °C

2.2: tetrahydrofuran / 18 h / -78 - 20 °C

3.1: Cs₂CO₃ / methanol / 18 h / 20 °C

4.1: H₂ / 10 percent Pd/C / tetrahydrofuran / 18 h / 20 °C

With dmap; hydrogen; caesium carbonate; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/S0968-0896(01)00295-4

Reference yield:

4-chlorobenzylamine (104-86-9) → (E)-N-(4-chlorobenzyl)-4-(1-(triphenylmethyl)imidazol-4-yl)-1-butanesulfonamide (220377-81-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 81 percent / Et₃N / CH₂Cl₂ / 2 h

2.1: 89 percent / N,N-4-dimethylaminopyridine / CH₂Cl₂ / 0.5 h

3.1: LDA / tetrahydrofuran / 1 h / -78 °C

3.2: tetrahydrofuran / 18 h / -78 - 20 °C

4.1: Cs₂CO₃ / methanol / 18 h / 20 °C

5.1: H₂ / 10 percent Pd/C / tetrahydrofuran / 18 h / 20 °C

With dmap; hydrogen; caesium carbonate; triethylamine; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/S0968-0896(01)00295-4

upstream raw materials:

(E)-N-(4-chlorobenzyl)-4-(1-(triphenylmethyl)imidazol-4-yl)-1-but-1-enesulfonamide

N-(4-chloro-benzyl)-methanesulfonamide

4-chlorobenzylamine

N-(tert-butoxycarbonyl)-N-(4-chlorobenzyl)-methanesulfonamide