Technology Process of N-{3-[(2-amino[1,2,4]triazolo[1,5-a]pyridin-6-yl)oxy]phenyl}-3-methylpyridine-2-carboxamide
There total 7 articles about N-{3-[(2-amino[1,2,4]triazolo[1,5-a]pyridin-6-yl)oxy]phenyl}-3-methylpyridine-2-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine;
In
methanol; ethanol;
at 80 ℃;
for 5h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 3 h / 20 °C
1.2: 13 h / 20 °C
2.1: dimethyl sulfoxide / 12 h / 20 °C
3.1: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / methanol; ethanol / 5 h / 80 °C
With
oxalyl dichloride; hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine;
N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: caesium carbonate / N,N-dimethyl-formamide / 15 h / 50 °C
2.1: hydrogen / palladium on activated charcoal / methanol / 12 h / 20 °C
3.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 3 h / 20 °C
3.2: 13 h / 20 °C
4.1: dimethyl sulfoxide / 12 h / 20 °C
5.1: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / methanol; ethanol / 5 h / 80 °C
With
oxalyl dichloride; hydroxylamine hydrochloride; hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal; N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
![ethyl {[5-(3-{[(3-methylpyridin-2-yl)carbonyl]amino}phenoxy)pyridin-2-yl]carbamothioyl}carbamate](/Databaselist/images/loading.webp)
