N-[3-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)phenyl]-3-methylpyridine-2-carboxamide

Base Information

Chemical Name:N-[3-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)phenyl]-3-methylpyridine-2-carboxamide
CAS No.:1092392-48-7
Molecular Formula:C₂₃H₂₀N₆O₃
Molecular Weight:428.45
Hs Code.:

Synonyms:N-[3-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)phenyl]-3-methylpyridine-2-carboxamide

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Chemical Property of N-[3-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)phenyl]-3-methylpyridine-2-carboxamide

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Technology Process of N-[3-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)phenyl]-3-methylpyridine-2-carboxamide

There total 8 articles about N-[3-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)phenyl]-3-methylpyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1092392-47-6
N-{3-[(2-amino[1,2,4]triazolo[1,5-a]pyridin-6-yl)oxy]phenyl}-3-methylpyridine-2-carboxamide

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1092392-48-7
N-[3-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)phenyl]-3-methylpyridine-2-carboxamide

Guidance literature:: N-{3-[(2-amino[1,2,4]triazolo[1,5-a]pyridin-6-yl)oxy]phenyl}-3-methylpyridine-2-carboxamide; cyclopropanecarboxylic acid chloride; In N,N-dimethyl acetamide; at 20 ℃; for 2h;

With water; sodium hydrogencarbonate; In N,N-dimethyl acetamide;

Reference yield:

: 4021-07-2
3-methyl-pyridine-2-carboxylic acid

: 1092392-48-7
N-[3-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)phenyl]-3-methylpyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 3 h / 20 °C

1.2: 13 h / 20 °C

2.1: dimethyl sulfoxide / 12 h / 20 °C

3.1: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / methanol; ethanol / 5 h / 80 °C

4.1: N,N-dimethyl acetamide / 2 h / 20 °C

With oxalyl dichloride; hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl acetamide; dimethyl sulfoxide;

Reference yield:

: 39856-50-3
5-bromo2-nitropyridine

: 1092392-48-7
N-[3-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)phenyl]-3-methylpyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 15 h / 50 °C

2.1: hydrogen / palladium on activated charcoal / methanol / 12 h / 20 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 3 h / 20 °C

3.2: 13 h / 20 °C

4.1: dimethyl sulfoxide / 12 h / 20 °C

5.1: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / methanol; ethanol / 5 h / 80 °C

6.1: N,N-dimethyl acetamide / 2 h / 20 °C

With oxalyl dichloride; hydroxylamine hydrochloride; hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl acetamide; dimethyl sulfoxide; N,N-dimethyl-formamide;