2-Amino-N-(benzyloxy)-acetamide

Base Information

• Chemical Name: 2-Amino-N-(benzyloxy)-acetamide
• CAS No.: 16975-23-8
• Molecular Formula: C9H12 N2 O2
• Molecular Weight: 180.206
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID50563115
• Nikkaji Number: J1.793.196B
• Wikidata: Q82447468
• Mol file: 16975-23-8.mol

Synonyms:2-Amino-N-(benzyloxy)-acetamide;16975-23-8;2-amino-N-phenylmethoxyacetamide;N-(Benzyloxy)glycinamide;2-Amino-N-(benzyloxy)acetamide;SCHEMBL7970712;DTXSID50563115;ADTJHTYWRYNWNF-UHFFFAOYSA-N;AKOS006295082;AB24869;AC-13401;J-010580

Chemical Property of 2-Amino-N-(benzyloxy)-acetamide

Chemical Property:

• Melting Point: 171-173 °C
• Refractive Index: 1.55
• Boiling Point: °Cat760mmHg
• PKA: 7.48±0.29(Predicted)
• Flash Point: °C
• PSA: 64.35000
• Density: 1.164g/cm³
• LogP: 1.28430
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 180.089877630
• Heavy Atom Count: 13
• Complexity: 156

Purity/Quality:

98%min ^*data from raw suppliers

2-AMINO-N-(BENZYLOXY)-ACETAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CONC(=O)CN

Technology Process of 2-Amino-N-(benzyloxy)-acetamide

There total 6 articles about 2-Amino-N-(benzyloxy)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(benzyloxycarbamoylmethyl)carbamic acid tert-butyl ester (63648-89-5) → O-benzylglycine hydroxamic acid (16975-23-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 0 ℃; for 1h;

DOI:10.1246/cl.1992.2009

Reference yield:

2-amino-N-benzyloxyacetamide 2,2,2-trifluoroacetic acid → O-benzylglycine hydroxamic acid (16975-23-8)

Guidance literature:

In methanol;

Reference yield:

N-benzyloxyamine (622-33-3) → O-benzylglycine hydroxamic acid (16975-23-8)

Guidance literature:

Multi-step reaction with 2 steps

1: isobutylchlorocarbonate

2: TFA / CH₂Cl₂

With trifluoroacetic acid; isobutyl chloroformate; In dichloromethane;

DOI:10.1039/b316246j

upstream raw materials:

N^α-Trifluoracetyl-glycin-hydroxymsaeure-benzylester

(benzyloxycarbamoylmethyl)carbamic acid tert-butyl ester

N-benzyloxyamine

O-benzylhydoxylamine hydrochloride

Downstream raw materials:

1-benzyloxy-5,6-dimethyl-2(1H)-pyrazinone

C₃₂H₃₅N₇O₆

1-benzyloxy-2(1H)-pyrazinone

3-(benzyloxy)imidazolidine-2,4-dione