N-(5-Acetyl-3-{[2-(4-fluorophenyl)-2-hydroxy-ethyl]-methyl-sulfamoyl}-thiophene-2-yl)-propionic acid amide

Base Information

Chemical Name:N-(5-Acetyl-3-{[2-(4-fluorophenyl)-2-hydroxy-ethyl]-methyl-sulfamoyl}-thiophene-2-yl)-propionic acid amide
CAS No.:864961-78-4
Molecular Formula:C₁₈H₂₁FN₂O₅S₂
Molecular Weight:428.506
Hs Code.:

Synonyms:N-(5-Acetyl-3-{[2-(4-fluorophenyl)-2-hydroxy-ethyl]-methyl-sulfamoyl}-thiophene-2-yl)-propionic acid amide

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Chemical Property of N-(5-Acetyl-3-{[2-(4-fluorophenyl)-2-hydroxy-ethyl]-methyl-sulfamoyl}-thiophene-2-yl)-propionic acid amide

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Technology Process of N-(5-Acetyl-3-{[2-(4-fluorophenyl)-2-hydroxy-ethyl]-methyl-sulfamoyl}-thiophene-2-yl)-propionic acid amide

There total 10 articles about N-(5-Acetyl-3-{[2-(4-fluorophenyl)-2-hydroxy-ethyl]-methyl-sulfamoyl}-thiophene-2-yl)-propionic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 864961-74-0
5-acetyl-2-amino-thiophene-3-sulfonic acid [2-(4-fluorophenyl)-2-hydroxy-ethyl]-methyl-amide

: 79-03-8
propionyl chloride

: 864961-78-4
N-(5-Acetyl-3-{[2-(4-fluorophenyl)-2-hydroxy-ethyl]-methyl-sulfamoyl}-thiophene-2-yl)-propionic acid amide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 2.5h;

Reference yield:

: 864961-70-6
(3-{[2-(4-Fluorophenyl)-2-hydroxy-ethyl]-methyl-sulfamoyl}-thiophene-2-yl)-carbamic acid t-butyl ester

: 864961-78-4
N-(5-Acetyl-3-{[2-(4-fluorophenyl)-2-hydroxy-ethyl]-methyl-sulfamoyl}-thiophene-2-yl)-propionic acid amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

2.1: cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2 h / 100 °C

2.2: 0.17 h

3.1: water; trifluoroacetic acid / 0.17 h

3.2: pH 11

4.1: triethylamine / tetrahydrofuran / 2.5 h / 20 °C

With N-Bromosuccinimide; water; triethylamine; cesium fluoride; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 864961-69-3
3-{[2-(4-Fluorophenyl)-2-hydroxy-ethyl]-methyl-sulfamoyl}-thiophene-2-carboxylic acid methyl ester

: 864961-78-4
N-(5-Acetyl-3-{[2-(4-fluorophenyl)-2-hydroxy-ethyl]-methyl-sulfamoyl}-thiophene-2-yl)-propionic acid amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: methanol; sodium hydroxide; water / tetrahydrofuran / 1 h / 20 °C

2.1: diphenyl phosphoryl azide; triethylamine / 2 h / 90 - 100 °C

3.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

4.1: cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2 h / 100 °C

4.2: 0.17 h

5.1: water; trifluoroacetic acid / 0.17 h

5.2: pH 11

6.1: triethylamine / tetrahydrofuran / 2.5 h / 20 °C

With methanol; sodium hydroxide; N-Bromosuccinimide; diphenyl phosphoryl azide; water; triethylamine; cesium fluoride; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;