N′-{2-chloro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}isovalerohydrazide

Base Information

Chemical Name:N′-{2-chloro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}isovalerohydrazide
CAS No.:1237587-28-8
Molecular Formula:C₂₁H₁₉Cl₃F₃N₃O₂
Molecular Weight:508.755
Hs Code.:

Synonyms:N′-{2-chloro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}isovalerohydrazide

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Chemical Property of N′-{2-chloro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}isovalerohydrazide

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Technology Process of N′-{2-chloro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}isovalerohydrazide

There total 11 articles about N′-{2-chloro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}isovalerohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1237587-27-7
tert-butyl N′-isovaleryl-N-{2-chloro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}carbazate

: 1237587-28-8
N′-{2-chloro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}isovalerohydrazide

Guidance literature:: tert-butyl N′-isovaleryl-N-{2-chloro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}carbazate; With trifluoroacetic acid; at 20 ℃; for 2h;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: 1071928-04-5
5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-chloronitrobenzene

: 1237587-28-8
N′-{2-chloro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}isovalerohydrazide

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid; iron / ethanol; water / 0.83 h / 75 °C

2.1: toluene; tetrahydrofuran / 1 h / 80 °C

2.2: 16 h / 20 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 20 °C

3.2: 15 h / 20 °C

4.1: triethylamine / tetrahydrofuran / 9 h / 0 - 20 °C

5.1: trifluoroacetic acid / tetrahydrofuran / 2 h / 20 °C

With iron; sodium hydride; acetic acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; water; toluene; mineral oil;

Reference yield:

: 66399-01-7
2-chloro-5-hydroxyiminomethylnitrobenzene

: 1237587-28-8
N′-{2-chloro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}isovalerohydrazide

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 1 h / 60 °C

1.2: 6 h

2.1: acetic acid; iron / ethanol; water / 0.83 h / 75 °C

3.1: toluene; tetrahydrofuran / 1 h / 80 °C

3.2: 16 h / 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 20 °C

4.2: 15 h / 20 °C

5.1: triethylamine / tetrahydrofuran / 9 h / 0 - 20 °C

6.1: trifluoroacetic acid / tetrahydrofuran / 2 h / 20 °C

With N-chloro-succinimide; iron; sodium hydride; acetic acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; toluene; mineral oil;