3-Oxo-3-(2-oxo-2-phenoxy-2λ⁵-[1,3,2]oxazaphosphinan-3-yl)-propionic acid ethyl ester

Base Information

• Chemical Name: 3-Oxo-3-(2-oxo-2-phenoxy-2λ⁵-[1,3,2]oxazaphosphinan-3-yl)-propionic acid ethyl ester
• CAS No.: 87791-45-5
• Molecular Formula: C₁₄H₁₈NO₆P
• Molecular Weight: 327.274

Synonyms:3-Oxo-3-(2-oxo-2-phenoxy-2λ⁵-[1,3,2]oxazaphosphinan-3-yl)-propionic acid ethyl ester

Chemical Property of 3-Oxo-3-(2-oxo-2-phenoxy-2λ⁵-[1,3,2]oxazaphosphinan-3-yl)-propionic acid ethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 3-Oxo-3-(2-oxo-2-phenoxy-2λ⁵-[1,3,2]oxazaphosphinan-3-yl)-propionic acid ethyl ester

There total 2 articles about 3-Oxo-3-(2-oxo-2-phenoxy-2λ⁵-[1,3,2]oxazaphosphinan-3-yl)-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

ethyl chlorocarbonylacetate (36239-09-5) + phenyl cyclophosphoramidate (50742-52-4) → 3-Oxo-3-(2-oxo-2-phenoxy-2λ5-[1,3,2]oxazaphosphinan-3-yl)-propionic acid ethyl ester (87791-45-5)

Guidance literature:

In tetrahydrofuran; for 15h;

DOI:10.1139/v83-296

Reference yield:

O-phenyl phosphorodichloridate (770-12-7) → 3-Oxo-3-(2-oxo-2-phenoxy-2λ5-[1,3,2]oxazaphosphinan-3-yl)-propionic acid ethyl ester (87791-45-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / pyridine / CH₂Cl₂ / 18 h / Ambient temperature

2: 84 percent / tetrahydrofuran / 15 h

With pyridine; In tetrahydrofuran; dichloromethane;

DOI:10.1139/v83-296

Reference yield: 85.0%

3-Oxo-3-(2-oxo-2-phenoxy-2λ5-[1,3,2]oxazaphosphinan-3-yl)-propionic acid ethyl ester (87791-45-5) → 2-Diazo-3-oxo-3-(2-oxo-2-phenoxy-2λ5-[1,3,2]oxazaphosphinan-3-yl)-propionic acid ethyl ester

Guidance literature:

With 4-toluenesulfonyl azide; triethylamine; In acetonitrile; for 40h; Ambient temperature;

DOI:10.1139/v83-296

upstream raw materials:

ethyl chlorocarbonylacetate

phenyl cyclophosphoramidate

O-phenyl phosphorodichloridate

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