N-[5-(4-dimethylamino-6-ethylpyrimidin-5-ylethynyl)-2-methylpyridin-3-yl]-4-fluorobenzenesulfonamide

Base Information

Chemical Name:N-[5-(4-dimethylamino-6-ethylpyrimidin-5-ylethynyl)-2-methylpyridin-3-yl]-4-fluorobenzenesulfonamide
CAS No.:1391978-21-4
Molecular Formula:C₂₂H₂₂FN₅O₂S
Molecular Weight:439.513
Hs Code.:

Synonyms:N-[5-(4-dimethylamino-6-ethylpyrimidin-5-ylethynyl)-2-methylpyridin-3-yl]-4-fluorobenzenesulfonamide

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Chemical Property of N-[5-(4-dimethylamino-6-ethylpyrimidin-5-ylethynyl)-2-methylpyridin-3-yl]-4-fluorobenzenesulfonamide

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Technology Process of N-[5-(4-dimethylamino-6-ethylpyrimidin-5-ylethynyl)-2-methylpyridin-3-yl]-4-fluorobenzenesulfonamide

There total 12 articles about N-[5-(4-dimethylamino-6-ethylpyrimidin-5-ylethynyl)-2-methylpyridin-3-yl]-4-fluorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1391979-30-8
N-[5-(4-chloro-6-ethyl-pyrimidin-5-ylethynyl)-2-methyl-pyridin-3-yl]-4-fluoro-benzenesulfonamide

: 124-40-3
dimethyl amine

: 1391978-21-4
N-[5-(4-dimethylamino-6-ethylpyrimidin-5-ylethynyl)-2-methylpyridin-3-yl]-4-fluorobenzenesulfonamide

Guidance literature:: In tetrahydrofuran; 1,4-dioxane; at 80 ℃; for 3h;

Reference yield:

: 67443-38-3
5-bromo-2-chloro-3-nitropyridine

: 1391978-21-4
N-[5-(4-dimethylamino-6-ethylpyrimidin-5-ylethynyl)-2-methylpyridin-3-yl]-4-fluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

1.2: 2 h / 0 - 50 °C

2.1: hydrogenchloride / water / 3 h / Reflux

3.1: ammonium chloride; iron / ethanol / 3 h / Reflux

4.1: diisopropylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 100 °C / Inert atmosphere

5.1: potassium carbonate; methanol / 3 h / 20 °C

6.1: pyridine / dichloromethane / 20 °C

7.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 65 °C / Inert atmosphere

8.1: 1,4-dioxane; tetrahydrofuran / 3 h / 80 °C

With pyridine; hydrogenchloride; methanol; iron; sodium hydride; potassium carbonate; ammonium chloride; triethylamine; diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 141602-29-1
4-chloro-5-iodo-6-ethylpyrimidine

: 1391978-21-4
N-[5-(4-dimethylamino-6-ethylpyrimidin-5-ylethynyl)-2-methylpyridin-3-yl]-4-fluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 65 °C / Inert atmosphere

2: 1,4-dioxane; tetrahydrofuran / 3 h / 80 °C

With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;