1-((1aR,3S,7bS)-1,1-Dibromo-5-methoxy-3-phenyl-1,1a,3,7b-tetrahydro-2-aza-cyclopropa[a]naphthalen-2-yl)-ethanone

Base Information

Chemical Name:1-((1aR,3S,7bS)-1,1-Dibromo-5-methoxy-3-phenyl-1,1a,3,7b-tetrahydro-2-aza-cyclopropa[a]naphthalen-2-yl)-ethanone
CAS No.:104576-38-7
Molecular Formula:C₁₉H₁₇Br₂NO₂
Molecular Weight:451.157
Hs Code.:

Synonyms:1-((1aR,3S,7bS)-1,1-Dibromo-5-methoxy-3-phenyl-1,1a,3,7b-tetrahydro-2-aza-cyclopropa[a]naphthalen-2-yl)-ethanone

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Chemical Property of 1-((1aR,3S,7bS)-1,1-Dibromo-5-methoxy-3-phenyl-1,1a,3,7b-tetrahydro-2-aza-cyclopropa[a]naphthalen-2-yl)-ethanone

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Technology Process of 1-((1aR,3S,7bS)-1,1-Dibromo-5-methoxy-3-phenyl-1,1a,3,7b-tetrahydro-2-aza-cyclopropa[a]naphthalen-2-yl)-ethanone

There total 3 articles about 1-((1aR,3S,7bS)-1,1-Dibromo-5-methoxy-3-phenyl-1,1a,3,7b-tetrahydro-2-aza-cyclopropa[a]naphthalen-2-yl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 75-25-2
Bromoform

: 104576-34-3
N-acetyl-7-methoxy-1-phenyl-1,2-dihydroisoquinoline

: 104576-38-7
1-((1aR,3S,7bS)-1,1-Dibromo-5-methoxy-3-phenyl-1,1a,3,7b-tetrahydro-2-aza-cyclopropa[a]naphthalen-2-yl)-ethanone

Guidance literature:: With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; for 4.5h;
DOI:10.1021/jo00372a009

Reference yield:

: 3278-19-1
N-[2-(4-methoxyphenyl)ethyl]benzamide

: 104576-38-7
1-((1aR,3S,7bS)-1,1-Dibromo-5-methoxy-3-phenyl-1,1a,3,7b-tetrahydro-2-aza-cyclopropa[a]naphthalen-2-yl)-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: 65 percent / P₂O₅, POCl₃ / xylene / Heating

2: 65 percent / AcOK / 6 h / Heating

3: 52 percent / 40percent aq. NaOH / benzyltriethyl ammonium chloride / 4.5 h

With sodium hydroxide; potassium acetate; phosphorus pentoxide; trichlorophosphate; N-benzyl-N,N,N-triethylammonium chloride; In xylene;
DOI:10.1021/jo00372a009

Reference yield:

: 104576-31-0
1-phenyl-7-methoxy-3,4-dihydro-isoquinoline

: 104576-38-7
1-((1aR,3S,7bS)-1,1-Dibromo-5-methoxy-3-phenyl-1,1a,3,7b-tetrahydro-2-aza-cyclopropa[a]naphthalen-2-yl)-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / AcOK / 6 h / Heating

2: 52 percent / 40percent aq. NaOH / benzyltriethyl ammonium chloride / 4.5 h

With sodium hydroxide; potassium acetate; N-benzyl-N,N,N-triethylammonium chloride;
DOI:10.1021/jo00372a009