104576-31-0

Basic information

• Product Name: 1-phenyl-7-methoxy-3,4-dihydro-isoquinoline
• Synonyms: 1-phenyl-7-methoxy-3,4-dihydro-isoquinoline
• CAS NO: 104576-31-0
• Molecular Weight: 237.301
• Mol File: 104576-31-0.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 1-phenyl-7-methoxy-3,4-dihydro-isoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenyl-7-methoxy-3,4-dihydro-isoquinoline(104576-31-0)
• EPA Substance Registry System: 1-phenyl-7-methoxy-3,4-dihydro-isoquinoline(104576-31-0)

Safety Data

• Hazardous Substances Data: 104576-31-0(Hazardous Substances Data)

Upstream product

• 702-23-8 2-(4-Methoxyphenyl)ethanol 
• 100-47-0 benzonitrile 
• 22246-04-4 7-methoxy-3,4-dihydro-2H-isoquinolin-1-one 
• 100-58-3 phenylmagnesium bromide 
• 72106-01-5 7-Methoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 1262842-01-2 C₂₃H₂₃NO₃S 
• 55-81-2 4-Methoxyphenethylamine 
• 98-88-4 benzoyl chloride 
• 3278-19-1 N-[2-(4-methoxyphenyl)ethyl]benzamide 

Downstream Products

• 159465-32-4 7-Methoxy-2-methyl-1-phenyl-1,2,3,4-tetrahydro-isoquinoline 
• 1381986-43-1 (R)-7-methoxy-1-phenyl-2-tosyl-1,2,3,4-tetrahydroisoquinoline 
• 104576-38-7 1-((1aR,3S,7bS)-1,1-Dibromo-5-methoxy-3-phenyl-1,1a,3,7b-tetrahydro-2-aza-cyclopropa[a]naphthalen-2-yl)-ethanone 
• 174784-49-7 2-benzyl-7-methoxy-1-methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 104576-34-3 N-acetyl-7-methoxy-1-phenyl-1,2-dihydroisoquinoline 
• 72106-01-5 7-Methoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

A Method for Bischler-Napieralski-Type Synthesis of 3,4-Dihydroisoquinolines

A new method for the Bischler-Napieralski-type synthesis of 3,4-dihydroisoquinolines was developed by a Tf2O-promoted tandem annulation from phenylethanols and nitriles. Its success was mainly due to the fact that a phenonium ion was formed in the process and practically functioned as a stable and reactive primary phenylethyl carbocation.

Method for solvent accelerated selective dehydrogenation of tetrahydroisoquinoline type compound

The invention discloses a method for synthesizing 1-substituted-3,4-dihydroisoquinoline through the solvent accelerated selective partial dehydrogenation of a 1-substituted-1,2,3,4-tetrahydroisoquinoline compound. For a simple and easily obtained cyclic amine type compound such as a tetrahydroisoquinoline compound, a corresponding imine compound can be obtained through selective dehydrogenation; the conversion ratio of the cyclic amine type compound is higher; further, the proportion of a partially dehydrogenated product to a fully dehydrogenated product is more than 20 to 1. The method is simple and convenient to operate, is practical, easy and feasible, and is mild in reaction condition; the actual cost is greatly reduced. In addition, a method for synthesizing 3,4-dihydroisoquinoline through the direct dehydrogenation of tetrahydroisoquinoline has the advantages of atom economy and environmental friendliness.

Solvent-promoted highly selective dehydrogenation of tetrahydroisoquinolines without catalyst and hydrogen acceptor

An unusual solvent DMF-promoted dehydrogenation of 1-substituted 1,2,3,4-tetrahydroisoquinolines to synthesize cyclic imines is described. This environmentally friendly reaction features no requirement of any metal catalysts, oxidants, or hydrogen acceptors. A wide range of structurally varied 3,4-dihydroisoquinolines can be obtained with good yields and excellent chemoselectivities.