3278-19-1

Basic information

• Product Name: N-[2-(4-methoxyphenyl)ethyl]benzamide
• Synonyms: benzamide, N-[2-(4-methoxyphenyl)ethyl]-; N-[2-(4-Methoxyphenyl)ethyl]benzamide
• CAS NO: 3278-19-1
• Molecular Formula: C₁₆H₁₇NO₂
• Molecular Weight: 255.3117
• Mol File: 3278-19-1.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 474.1°C at 760 mmHg
• Flash Point: 240.5°C
• Density: 1.105g/cm³
• Vapor Pressure: 3.73E-09mmHg at 25°C
• Refractive Index: 1.568
• CAS DataBase Reference: N-[2-(4-methoxyphenyl)ethyl]benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-(4-methoxyphenyl)ethyl]benzamide(3278-19-1)
• EPA Substance Registry System: N-[2-(4-methoxyphenyl)ethyl]benzamide(3278-19-1)

Safety Data

• Hazardous Substances Data: 3278-19-1(Hazardous Substances Data)

Usage

General Description

N-[2-(4-methoxyphenyl)ethyl]benzamide is a chemical compound with the molecular formula C16H17NO2. It is classified as an amide, which is a functional group containing a carbonyl group linked to a nitrogen atom. The compound consists of a benzene ring attached to a 2-(4-methoxyphenyl)ethyl group, which in turn is linked to a carbonyl group. N-[2-(4-methoxyphenyl)ethyl]benzamide may have potential applications in the fields of pharmaceuticals, agrochemicals, and materials science, due to its structural features and potential biological activities. Further studies and research are needed to determine its specific uses and potential benefits.

Upstream product

• 104-92-7 1-bromo-4-methoxy-benzene 
• 26385-07-9 N-(2-chloro-ethyl)-benzamide 
• 98-88-4 benzoyl chloride 
• 55-81-2 4-Methoxyphenethylamine 
• 104-47-2 p-methoxybenzylnitrile 
• 645-58-9 4-methoxyphenethylamine hydrochloride 
• 100-51-6 benzyl alcohol 
• 98-86-2 acetophenone 
• 637-69-4 4-Methoxystyrene 
• 55-21-0 benzamide 
• 30148-17-5 (1-methyl-1H-imidazol-2-yl)(phenyl)methanone 
• 99802-96-7 2-benzoyl-1,3-dimethyl-1H-imidazol-3-ium iodide 
• 611-74-5 N,N-dimethylbenzamide 
• 140-29-4 phenylacetonitrile 

Downstream Products

• 104576-31-0 1-phenyl-7-methoxy-3,4-dihydro-isoquinoline 
• 72106-01-5 7-Methoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 159465-32-4 7-Methoxy-2-methyl-1-phenyl-1,2,3,4-tetrahydro-isoquinoline 
• 112725-02-7 2-phenyl-5-p.methoxyphenyl-4,5-dihydrooxazole 
• 113934-87-5 N-(2-(4-methoxyphenyl)-1-vinyl)benzamide 
• 104576-38-7 1-((1aR,3S,7bS)-1,1-Dibromo-5-methoxy-3-phenyl-1,1a,3,7b-tetrahydro-2-aza-cyclopropa[a]naphthalen-2-yl)-ethanone 
• 104576-34-3 N-acetyl-7-methoxy-1-phenyl-1,2-dihydroisoquinoline 
• 25263-48-3 1,2,3,4-tetrahydro-6-methoxy-1-phenyl-isoquinoline 
• 19712-49-3 6-methoxy-1-phenyl-3,4-dihydroisoquinoline 
• 15298-31-4 1-acetoxy-2-benzoylamino-1-(4-methoxy-phenyl)-ethane 
• 21404-68-2 4-[N-(4-methoxy-phenethyl)-benzimidoyl]-morpholine 

Relevant articles and documents

Base-Mediated Anti-Markovnikov Hydroamidation of Vinyl Arenes with Arylamides

We investigated a base-promoted protocol for the intermolecular anti-Markovnikov hydroamidation of vinyl arenes with arylamides to furnish the arylethylbenzamides with excellent chemo- and regioselectivity. The reaction tolerates an extensive variety of functional groups and has been successfully extended with electronically varied handles, aminobenzamides, electron-rich/electron-deficient heterocyclic amides, and vinyl arenes to afford the hydroamidated products. Excellent chemoselectivity was observed for the amide group over amine. The proposed mechanism and vital role of the solvent was well supported by deuterium labeling studies and control experiments.

Imidazolium chloride: An efficient catalyst for transamidation of primary amines

A highly efficient and convenient protocol of imidazolium chloride (30 mol %) catalyzed amidation of amines with moderate to excellent yields was reported. The protocol shows broad substrate scope for aromatic, aliphatic, and heterocyclic primary amines.

Iron-catalyzed benzamide formation. Application to the synthesis of moclobemide

A convenient and user-friendly method to yield benzamides from primary and secondary amines and various benzylic alcohols in the presence of a cheap iron salt (FeCl2·4H2O) and tert-butylhydroperoxide (70% in water) as a stoichiometric oxidant is described. Control experiments indicated that this reaction might involve radical species. This method proved to be general, generating a family of 30 benzamides and was applied to the preparative synthesis of anti-anxiety drug moclobemide.