3278-19-1

Usage

Uses

Used in Pharmaceutical Industry:
N-[2-(4-methoxyphenyl)ethyl]benzamide is used as a potential pharmaceutical compound for its possible biological activities. Its specific applications and benefits in this industry are yet to be determined through further studies and research.
Used in Agrochemical Industry:
N-[2-(4-methoxyphenyl)ethyl]benzamide is used as a potential agrochemical compound for its possible applications in this field. Further research is needed to explore its potential uses and benefits in agriculture.
Used in Materials Science:
N-[2-(4-methoxyphenyl)ethyl]benzamide is used as a potential material in materials science due to its structural features. Its specific applications and advantages in this field are yet to be discovered through additional studies and research.

Upstream product

• 55-81-2 4-Methoxyphenethylamine 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 26385-07-9 N-(2-chloro-ethyl)-benzamide 
• 98-88-4 benzoyl chloride 
• 104-47-2 p-methoxybenzylnitrile 
• 645-58-9 4-methoxyphenethylamine hydrochloride 
• 100-51-6 benzyl alcohol 
• 98-86-2 acetophenone 
• 637-69-4 4-Methoxystyrene 
• 55-21-0 benzamide 
• 30148-17-5 (1-methyl-1H-imidazol-2-yl)(phenyl)methanone 
• 99802-96-7 2-benzoyl-1,3-dimethyl-1H-imidazol-3-ium iodide 
• 611-74-5 N,N-dimethylbenzamide 
• 140-29-4 phenylacetonitrile 

Downstream Products

• 104576-31-0 1-phenyl-7-methoxy-3,4-dihydro-isoquinoline 
• 15298-31-4 1-acetoxy-2-benzoylamino-1-(4-methoxy-phenyl)-ethane 
• 19712-49-3 6-methoxy-1-phenyl-3,4-dihydroisoquinoline 
• 25263-48-3 1,2,3,4-tetrahydro-6-methoxy-1-phenyl-isoquinoline 
• 72106-01-5 7-Methoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 113934-87-5 N-(2-(4-methoxyphenyl)-1-vinyl)benzamide 
• 112725-02-7 2-phenyl-5-p.methoxyphenyl-4,5-dihydrooxazole 
• 104576-38-7 1-((1aR,3S,7bS)-1,1-Dibromo-5-methoxy-3-phenyl-1,1a,3,7b-tetrahydro-2-aza-cyclopropa[a]naphthalen-2-yl)-ethanone 
• 104576-34-3 N-acetyl-7-methoxy-1-phenyl-1,2-dihydroisoquinoline 
• 159465-32-4 7-Methoxy-2-methyl-1-phenyl-1,2,3,4-tetrahydro-isoquinoline 
• 21404-68-2 4-[N-(4-methoxy-phenethyl)-benzimidoyl]-morpholine 

Relevant academic research and scientific papers

Base-Mediated Anti-Markovnikov Hydroamidation of Vinyl Arenes with Arylamides

We investigated a base-promoted protocol for the intermolecular anti-Markovnikov hydroamidation of vinyl arenes with arylamides to furnish the arylethylbenzamides with excellent chemo- and regioselectivity. The reaction tolerates an extensive variety of functional groups and has been successfully extended with electronically varied handles, aminobenzamides, electron-rich/electron-deficient heterocyclic amides, and vinyl arenes to afford the hydroamidated products. Excellent chemoselectivity was observed for the amide group over amine. The proposed mechanism and vital role of the solvent was well supported by deuterium labeling studies and control experiments.

Base-Promoted Amidation and Esterification of Imidazolium Salts via Acyl C-C bond Cleavage: Access to Aromatic Amides and Esters

Imidazolium salts have been effectively employed as suitable acyl transfer agents in amidation and esterification in organic synthesis. The weak acyl C(O)-C imidazolium bond was exploited to generate acyl electrophiles, which further react with amines and alcohols to afford amides and esters. The broad substrate scope of anilines and benzylic amines and base-promoted conditions are the benefits of this route. Interestingly, phenol, benzylic alcohols, and a biologically active alcohol can also be subjected to esterification under the optimized conditions.

Imidazolium chloride: An efficient catalyst for transamidation of primary amines

A highly efficient and convenient protocol of imidazolium chloride (30 mol %) catalyzed amidation of amines with moderate to excellent yields was reported. The protocol shows broad substrate scope for aromatic, aliphatic, and heterocyclic primary amines.

A method for synthesis of amides

The invention discloses a synthesizing method for an amide compound shown in formula (III). The synthesizing method comprises the following steps: adopting replacing acetonitrile shown in formula (I) and amines compound shown in formula (II) as raw materials in air atmosphere; adopting Ru/C as a catalyst; conducting reaction in solvent to generate the amide compound shown in formula (III); the solvent is one selected from ethyl alcohol, furanidine, methyl sulfoxide and o-dichlorobenzene. The synthesizing method being novel synthesizing route is simple to operate, convenient in post-treatment, high in product yield, and good in product purity; particularly, the catalyst and the solvent can be used repeatedly; air is taken as oxidant; not only production cost is reduced, but also the method is environmental-friendly, and very suitable for large-scale industrialization production.

Metal free amide synthesis via carbon-carbon bond cleavage

A metal-free oxidative coupling of methyl ketones and primary amines to amides has been developed. The reaction tolerates a variety of functional groups, and is operationally simple. The reaction is proposed to go through a radical pathway to form the triiodomethyl ketone intermediate and the amide is formed by the nucleophilic attack of amine on triiodomethyl ketone carbonyl.

Iron-catalyzed benzamide formation. Application to the synthesis of moclobemide

A convenient and user-friendly method to yield benzamides from primary and secondary amines and various benzylic alcohols in the presence of a cheap iron salt (FeCl2·4H2O) and tert-butylhydroperoxide (70% in water) as a stoichiometric oxidant is described. Control experiments indicated that this reaction might involve radical species. This method proved to be general, generating a family of 30 benzamides and was applied to the preparative synthesis of anti-anxiety drug moclobemide.

Iron-catalyzed benzamide formation. Application to the synthesis of moclobemide

A convenient and user-friendly method to yield benzamides from primary and secondary amines and various benzylic alcohols in the presence of a cheap iron salt (FeCl2$4H2O) and tert-butylhydroperoxide (70% in water) as a stoichiometric oxidant is described. Control experiments indicated that this reaction might involve radical species. This method proved to be general, generating a family of 30 benzamides and was applied to the preparative synthesis of anti-anxiety drug moclobemide.

SUBSTITUTED 4-(1,2,3,4-TETRAHYDROISOQUINOLIN-2-YL)-4-OXORUTYRIC ACID AMIDE AS KCNQ2/3 MODULATORS

The invention relates to substituted tetrahydroisoquinolinyl-4-oxobutyric acid amides, methods for the preparation thereof, medicinal products containing these compounds and the use of these compounds for the preparation of medicinal products

Synthesis and Molecular Modeling of 1-Phenyl-1,2,3,4-tetrahydroisoquinolines and Related 5,6,8,9-Tetrahydro-13bH-dibenzoquinolizines as D1 Dopamine Antagonists

New 1-phenyl-1,2,3,4-tetrahydroisoquinolines and related 5,6,8,9-tetrahydro-13bH-dibenzo-quinolizines were prepared as ring-contracted analogs of the prototypical 1-phenyl-2,3,4,5-tetrahydrobenzazepines (e.g., SCH23390) as a continuation of our studi

Direct Coupling of Functionalized Organolithium Compounds with Aryl and Vinyl Halides

The reaction between β- and γ-nitrogen-functionalized and γ- and ε-oxygen-functionalized organolithium compounds 3, 4, 30-32 and different aromatic, heteroaromatic, and vinylic halides affords directly the corresponding substitution products: functionalized benzamides 5-26 and alcohols 33-37.Symmetrical and mixed products of double coupling 38-40 were also prepared from 1,4-diiodobenzene.The formation of alkyl halides as intermediates has been verified.Aryl or vinyl halides giving rise to unstable aryl or vinyllithium reagents were unsuccessful in the coupling reaction.