N₄-propionyl cytosine

Base Information

• Chemical Name: N₄-propionyl cytosine
• CAS No.: 21261-08-5
• Molecular Formula: C₇H₉N₃O₂
• Molecular Weight: 167.167
• Mol file: 21261-08-5.mol

Synonyms:N₄-propionyl cytosine

Chemical Property of N₄-propionyl cytosine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₄-propionyl cytosine

There total 2 articles about N₄-propionyl cytosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Cytosine (71-30-7) + propionic acid anhydride (123-62-6) → N4-propionyl cytosine (21261-08-5)

Guidance literature:

With pyridine; dmap; In toluene; at 25 - 58 ℃;

Reference yield:

propionic acid anhydride (123-62-6) + cytosine (71-30-7,66398-98-9,66460-16-0) → N4-propionyl cytosine (21261-08-5)

Guidance literature:

propionic acid anhydride; cytosine; With pyridine; dmap; In toluene; at 75 ℃; for 1h;

With triethylamine; In water; at 20 ℃; for 3h;

Reference yield:

N4-propionyl cytosine (21261-08-5) + (1'R,2'S,5'R)-menthyl-5(R,S)-acetoxy-[1,3]-oxathiolane-2R-carboxylate (1144099-18-2,147126-67-8) → (2R,5S)-5-(N-4-propionylcytosin-1-yl)-1,3-oxathiolane-2R-carboxylic acid (1'R,2'S,5'R)-menthyl ester (1235712-37-4)

Guidance literature:

N₄-propionyl cytosine; With methanesulfonic acid; 1,1,1,3,3,3-hexamethyl-disilazane; In toluene; at 20 - 113 ℃;

(1'R,2'S,5'R)-menthyl-5(R,S)-acetoxy-[1,3]-oxathiolane-2R-carboxylate; With triphenylmethyl perchlorate; In dichloromethane; toluene; at 10 - 56 ℃; Inert atmosphere;

upstream raw materials:

Cytosine

propionic acid anhydride

cytosine

Downstream raw materials:

(2R,5S)-5-(N-4-propionylcytosin-1-yl)-1,3-oxathiolane-2R-carboxylic acid (1'R,2'S,5'R)-menthyl ester