methyl 3-methyl-4-{[(6-{[(5-methyl-2-furyl)sulfonyl]amino}-2,3-dihydro-1H-inden-5-yl)oxy]methyl}benzoate

Base Information

Chemical Name:methyl 3-methyl-4-{[(6-{[(5-methyl-2-furyl)sulfonyl]amino}-2,3-dihydro-1H-inden-5-yl)oxy]methyl}benzoate
CAS No.:916913-89-8
Molecular Formula:C₂₄H₂₅NO₆S
Molecular Weight:455.532
Hs Code.:

Synonyms:methyl 3-methyl-4-{[(6-{[(5-methyl-2-furyl)sulfonyl]amino}-2,3-dihydro-1H-inden-5-yl)oxy]methyl}benzoate

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Chemical Property of methyl 3-methyl-4-{[(6-{[(5-methyl-2-furyl)sulfonyl]amino}-2,3-dihydro-1H-inden-5-yl)oxy]methyl}benzoate

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Technology Process of methyl 3-methyl-4-{[(6-{[(5-methyl-2-furyl)sulfonyl]amino}-2,3-dihydro-1H-inden-5-yl)oxy]methyl}benzoate

There total 8 articles about methyl 3-methyl-4-{[(6-{[(5-methyl-2-furyl)sulfonyl]amino}-2,3-dihydro-1H-inden-5-yl)oxy]methyl}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 69815-95-8
5-methylfuran-2-sulfonyl chloride

: 916913-84-3
methyl 3-methyl-4-{[(6-amino-2,3-dihydro-1H-inden-5-yl)oxy]methyl}benzoate

: 916913-89-8
methyl 3-methyl-4-{[(6-{[(5-methyl-2-furyl)sulfonyl]amino}-2,3-dihydro-1H-inden-5-yl)oxy]methyl}benzoate

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/j.bmc.2006.08.001

Reference yield:

: 68837-59-2
4-bromo-2-methylbenzoic acid

: 916913-89-8
methyl 3-methyl-4-{[(6-{[(5-methyl-2-furyl)sulfonyl]amino}-2,3-dihydro-1H-inden-5-yl)oxy]methyl}benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: 47 percent / lithium aluminum hydride / tetrahydrofuran / 0.17 h / 20 °C

2: 61 percent / triethylamine; dppf / Pd(OAc)2 / dimethylsulfoxide / 2 h / 70 °C

3: 95 percent / PBr₃ / various solvent(s) / 0.5 h / -6 °C

4: 98 percent / potassium carbonate / dimethylformamide / 4 h / 50 °C

5: 96 percent / acetic acid; iron / H₂O / 1 h

6: 64 percent / pyridine / CH₂Cl₂ / 1 h / 20 °C

With pyridine; 1,1'-bis-(diphenylphosphino)ferrocene; lithium aluminium tetrahydride; phosphorus tribromide; iron; potassium carbonate; acetic acid; triethylamine; palladium diacetate; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.08.001

Reference yield:

: 17100-58-2
4-bromo-2-methylbenzyl alcohol

: 916913-89-8
methyl 3-methyl-4-{[(6-{[(5-methyl-2-furyl)sulfonyl]amino}-2,3-dihydro-1H-inden-5-yl)oxy]methyl}benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 61 percent / triethylamine; dppf / Pd(OAc)2 / dimethylsulfoxide / 2 h / 70 °C

2: 95 percent / PBr₃ / various solvent(s) / 0.5 h / -6 °C

3: 98 percent / potassium carbonate / dimethylformamide / 4 h / 50 °C

4: 96 percent / acetic acid; iron / H₂O / 1 h

5: 64 percent / pyridine / CH₂Cl₂ / 1 h / 20 °C

With pyridine; 1,1'-bis-(diphenylphosphino)ferrocene; phosphorus tribromide; iron; potassium carbonate; acetic acid; triethylamine; palladium diacetate; In dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.08.001