ethyl 3-[benzyl(4-cyanocyclohex-3-en-1-yl)amino]-2,2-dichloro-3-oxopropanoate

Base Information

Chemical Name:ethyl 3-[benzyl(4-cyanocyclohex-3-en-1-yl)amino]-2,2-dichloro-3-oxopropanoate
CAS No.:1610517-29-7
Molecular Formula:C₁₉H₂₀Cl₂N₂O₃
Molecular Weight:395.285
Hs Code.:

Synonyms:ethyl 3-[benzyl(4-cyanocyclohex-3-en-1-yl)amino]-2,2-dichloro-3-oxopropanoate

Suppliers and Price of ethyl 3-[benzyl(4-cyanocyclohex-3-en-1-yl)amino]-2,2-dichloro-3-oxopropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 3-[benzyl(4-cyanocyclohex-3-en-1-yl)amino]-2,2-dichloro-3-oxopropanoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of ethyl 3-[benzyl(4-cyanocyclohex-3-en-1-yl)amino]-2,2-dichloro-3-oxopropanoate

There total 4 articles about ethyl 3-[benzyl(4-cyanocyclohex-3-en-1-yl)amino]-2,2-dichloro-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1610517-27-5
2,2-dichloro-2-ethoxycarbonylacetyl chloride

: 187807-19-8
4-(benzylamino)cyclohex-1-encarbonitrile

: 1610517-29-7
ethyl 3-[benzyl(4-cyanocyclohex-3-en-1-yl)amino]-2,2-dichloro-3-oxopropanoate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1002/ejoc.201301590

Reference yield:

: 188562-91-6
tert-butyl N-benzyl(4-oxocyclohexyl)carbamate

: 1610517-29-7
ethyl 3-[benzyl(4-cyanocyclohex-3-en-1-yl)amino]-2,2-dichloro-3-oxopropanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: cesium fluoride / acetonitrile / 20 °C / Inert atmosphere

1.2: 5 h / Inert atmosphere; Reflux

2.1: hydrogenchloride; water / tetrahydrofuran / 5 h / Reflux

3.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; water; triethylamine; cesium fluoride; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1002/ejoc.201301590

Reference yield:

: 36239-09-5
ethyl chlorocarbonylacetate

: 1610517-29-7
ethyl 3-[benzyl(4-cyanocyclohex-3-en-1-yl)amino]-2,2-dichloro-3-oxopropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuryl dichloride

2: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With sulfuryl dichloride; triethylamine; In dichloromethane;
DOI:10.1002/ejoc.201301590