187807-19-8

Upstream product

• 422507-45-7 4-benzylamino-1-trimethylsilyloxycyclohexane-1-carbonitrile 
• 7677-24-9 trimethylsilyl cyanide 
• 142009-99-2 4-(benzylamino)cyclohexane-1-one 
• 422507-48-0 [N-benzyl-N-(4-cyano-3-cyclohexenyl)amino]phosphonic dichloride 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 100-46-9 benzylamine 
• 230287-23-7 N-(1,4-dioxaspiro[4.5]decyl-7-idene)benzylamine 
• 131511-13-2 4-(N-benzylamino)cyclohexanone ethylene acetal 
• 188562-91-6 tert-butyl N-benzyl(4-oxocyclohexyl)carbamate 

Downstream Products

• 188563-09-9 N-Benzyl-2-chloro-N-(4-cyano-cyclohex-3-enyl)-acetamide 
• 422506-79-4 4-[N-benzyl-N-(methoxycarbonylmethyl)amino]cyclohex-1-enecarbonitrile 
• 422507-26-4 4-[N-benzyl-N-(2-methoxycarbonylethyl)amino]-1-cyclohexenecarbonitrile 
• 1610517-29-7 ethyl 3-[benzyl(4-cyanocyclohex-3-en-1-yl)amino]-2,2-dichloro-3-oxopropanoate 
• 188563-13-5 N-Benzyl-N-(4-cyano-cyclohex-3-enyl)-2-iodo-acetamide 

Relevant academic research and scientific papers

Synthesis of the tetracyclic ABCD ring systems of madangamines D-F

Synthesis of the tetracyclic cores of madangamines D-F was achieved, featuring a reductive radical process from an ethoxycarbonyldichloroacetamide to build the morphan nucleus, a Mitsunobu-type aminocyclization toward the common diazatricyclic intermediate, and ring-closing metathesis reactions for the macrocyclization step leading to the 13- to 15-membered rings.

Chlorine atom transfer radical 6-exo cyclizations of carbamoyldichloroacetate-tethered alkenes, enol acetates and α,β-unsaturated nitriles leading to morphans

The CuI-mediated atom transfer radical cyclization of amino-tethered dichloromalonamides and electron-rich, electron-poor, and nonactivated double bonds is a useful methodology for the synthesis of 2-azabicyclo[3.3.1]nonanes. A study of the rea

Decarbonylative radical cyclization of α-amino selenoesters upon electrophilic alkenes. A general method for the 6-azabicyclo[3.2.1]octane synthesis

α-Amino selenoester-tethered electronically poor alkenes on treatment with tributyltin hydride or TTMSS undergo intramolecular radical cyclization to provide 6-azabicyclo[3.2.1]octanes through 1-aminomethyl radical intermediates.

A New Method to Generate α-Aminoalkyl Radicals: Treatment of Methyl α-Amino Selenoesters with Hydride Reagents. Synthesis of 6-Azabicyclo[3.2.1]octanes by Radical Cyclization

A new method to generate α-aminoalkyl radicals and its application to the synthesis of 6-azabicyclo[3.2.1]octanes is described. α-Amino selenoesters on heating with Bu3SnH or (Me3Si)3SiH undergo decarbonylation of the initially formed acyl radical to give the corresponding α-amino radical which could be trapped intramolecularly with a double bond bearing an electron-withdrawing group.