5-nitro-1-((4-(3-trifluoromethylphenyl)piperazin-1-yl)methyl)indolin-2,3-dione

Base Information

Chemical Name:5-nitro-1-((4-(3-trifluoromethylphenyl)piperazin-1-yl)methyl)indolin-2,3-dione
CAS No.:314026-20-5
Molecular Formula:C₂₀H₁₇F₃N₄O₄
Molecular Weight:434.375
Hs Code.:

Synonyms:5-nitro-1-((4-(3-trifluoromethylphenyl)piperazin-1-yl)methyl)indolin-2,3-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-nitro-1-((4-(3-trifluoromethylphenyl)piperazin-1-yl)methyl)indolin-2,3-dione

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Technology Process of 5-nitro-1-((4-(3-trifluoromethylphenyl)piperazin-1-yl)methyl)indolin-2,3-dione

There total 2 articles about 5-nitro-1-((4-(3-trifluoromethylphenyl)piperazin-1-yl)methyl)indolin-2,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 611-09-6
5-nitroisatin

: 15532-75-9
1-(3-Trifluoromethylphenyl)piperazine

: 314026-20-5
5-nitro-1-((4-(3-trifluoromethylphenyl)piperazin-1-yl)methyl)indolin-2,3-dione

Guidance literature:: In ethanol; at 20 ℃; for 51h; Cooling;
DOI:10.1007/s12272-013-0062-1

Reference yield:

: 91-56-5,1186480-61-4,84788-92-1
indole-2,3-dione

: 314026-20-5
5-nitro-1-((4-(3-trifluoromethylphenyl)piperazin-1-yl)methyl)indolin-2,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1: nitric acid; sulfuric acid / 1 h / 60 °C / Cooling with ice

2: ethanol / 51 h / 20 °C / Cooling

With sulfuric acid; nitric acid; In ethanol; 2: |Mannich Aminomethylation;
DOI:10.1007/s12272-013-0062-1

Reference yield: 64.0%

: 314026-20-5
5-nitro-1-((4-(3-trifluoromethylphenyl)piperazin-1-yl)methyl)indolin-2,3-dione

: 1426684-99-2
5-amino-1-((4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)methyl)indolin-2,3-dione

Guidance literature:: 5-nitro-1-((4-(3-trifluoromethylphenyl)piperazin-1-yl)methyl)indolin-2,3-dione; With iron; In ethanol; at 80 - 85 ℃;

With hydrogenchloride; In ethanol; water; at 80 - 85 ℃; for 4h;
DOI:10.1007/s12272-013-0062-1