3-(2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-9-(2-N-benzylcarbamyl-ethoxy)-1,3-diaza-2-oxophenoxazine

Base Information

Chemical Name:3-(2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-9-(2-N-benzylcarbamyl-ethoxy)-1,3-diaza-2-oxophenoxazine
CAS No.:1188523-06-9
Molecular Formula:C₂₅H₂₅FN₄O₈
Molecular Weight:528.494
Hs Code.:

Synonyms:3-(2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-9-(2-N-benzylcarbamyl-ethoxy)-1,3-diaza-2-oxophenoxazine

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Chemical Property of 3-(2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-9-(2-N-benzylcarbamyl-ethoxy)-1,3-diaza-2-oxophenoxazine

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Technology Process of 3-(2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-9-(2-N-benzylcarbamyl-ethoxy)-1,3-diaza-2-oxophenoxazine

There total 6 articles about 3-(2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-9-(2-N-benzylcarbamyl-ethoxy)-1,3-diaza-2-oxophenoxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1188523-04-7
5-bromo-3',5'-diacetyl-N₄-(2-(2-N-benzylcarbamyl-ethoxy)-6-hydroxyphenyl)-2'-fluoro-2'-deoxycytidine

: 1188523-06-9
3-(2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-9-(2-N-benzylcarbamyl-ethoxy)-1,3-diaza-2-oxophenoxazine

Guidance literature:: 5-bromo-3',5'-diacetyl-N₄-(2-(2-N-benzylcarbamyl-ethoxy)-6-hydroxyphenyl)-2'-fluoro-2'-deoxycytidine; With triethylamine; In ethanol; at 90 ℃; for 8h;

With ammonium hydroxide; In ethanol; at 20 ℃; for 3h;

Reference yield:

: 1188522-93-1
C₁₅H₁₅BrFN₅O₆

: 1188523-06-9
3-(2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-9-(2-N-benzylcarbamyl-ethoxy)-1,3-diaza-2-oxophenoxazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 18 h / 20 °C

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / Cooling with ice

3.1: triethylamine / ethanol / 8 h / 90 °C

3.2: 3 h / 20 °C

With di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; In ethanol; dichloromethane;

Reference yield:

: 1188522-91-9
5-bromo-3',5'-diacetyl-2'-fluoro-2'-deoxyuridine

: 1188523-06-9
3-(2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-9-(2-N-benzylcarbamyl-ethoxy)-1,3-diaza-2-oxophenoxazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,2,3-triazole; triethylamine; trichlorophosphate / acetonitrile / 3.33 h / 0 - 20 °C

2.1: triethylamine / dichloromethane / 18 h / 20 °C

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / Cooling with ice

4.1: triethylamine / ethanol / 8 h / 90 °C

4.2: 3 h / 20 °C

With 1,2,3-triazole; di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; trichlorophosphate; In ethanol; dichloromethane; acetonitrile;