8-benzyl-6-(4-(dimethylamino)phenyl)-2-(4-hydroxybenzylidene)imidazo[1,2-a]pyrazin-3(2H)-one

Base Information

Chemical Name:8-benzyl-6-(4-(dimethylamino)phenyl)-2-(4-hydroxybenzylidene)imidazo[1,2-a]pyrazin-3(2H)-one
CAS No.:853941-58-9
Molecular Formula:C₂₈H₂₄N₄O₂
Molecular Weight:448.524
Hs Code.:

Synonyms:8-benzyl-6-(4-(dimethylamino)phenyl)-2-(4-hydroxybenzylidene)imidazo[1,2-a]pyrazin-3(2H)-one

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Chemical Property of 8-benzyl-6-(4-(dimethylamino)phenyl)-2-(4-hydroxybenzylidene)imidazo[1,2-a]pyrazin-3(2H)-one

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Technology Process of 8-benzyl-6-(4-(dimethylamino)phenyl)-2-(4-hydroxybenzylidene)imidazo[1,2-a]pyrazin-3(2H)-one

There total 4 articles about 8-benzyl-6-(4-(dimethylamino)phenyl)-2-(4-hydroxybenzylidene)imidazo[1,2-a]pyrazin-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1268631-67-9
8-benzyl-2-(4-hydroxybenzyl)-3-oxo-3,7-dihydroimidazo[1,2-a]pyrazin-6-yl trifluoromethanesulfonate

: 28611-39-4
4-(dimethylamino)benzene-boronic acid

: 853941-58-9
8-benzyl-6-(4-(dimethylamino)phenyl)-2-(4-hydroxybenzylidene)imidazo[1,2-a]pyrazin-3(2H)-one

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 40 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.tet.2010.12.001

Reference yield:

: 853941-51-2
5-amino-6-benzyl-2-O-trifluoromethanesulfonyloxypyrazine

: 853941-58-9
8-benzyl-6-(4-(dimethylamino)phenyl)-2-(4-hydroxybenzylidene)imidazo[1,2-a]pyrazin-3(2H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane; water / 3 h / 80 °C / Inert atmosphere

2: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 1 h / 40 °C / Inert atmosphere

With hydrogenchloride; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; 2: Suzuki-Miyaura coupling;
DOI:10.1016/j.tet.2010.12.001

Reference yield:

: 671240-60-1
C₁₈H₁₇N₃O₃S

: 853941-58-9
8-benzyl-6-(4-(dimethylamino)phenyl)-2-(4-hydroxybenzylidene)imidazo[1,2-a]pyrazin-3(2H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

2: sulfuric acid / 0 °C

3: hydrogenchloride / 1,4-dioxane; water / 3 h / 80 °C / Inert atmosphere

4: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 1 h / 40 °C / Inert atmosphere

With hydrogenchloride; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; water; 4: Suzuki-Miyaura coupling;
DOI:10.1016/j.tet.2010.12.001