8-benzyl-2-(4-hydroxybenzyl)-3-oxo-3,7-dihydroimidazo[1,2-a]pyrazin-6-yl trifluoromethanesulfonate

Base Information

• Chemical Name: 8-benzyl-2-(4-hydroxybenzyl)-3-oxo-3,7-dihydroimidazo[1,2-a]pyrazin-6-yl trifluoromethanesulfonate
• CAS No.: 1268631-67-9
• Molecular Formula: C₂₁H₁₆F₃N₃O₅S
• Molecular Weight: 479.436
• Mol file: 1268631-67-9.mol

Synonyms:8-benzyl-2-(4-hydroxybenzyl)-3-oxo-3,7-dihydroimidazo[1,2-a]pyrazin-6-yl trifluoromethanesulfonate

Chemical Property of 8-benzyl-2-(4-hydroxybenzyl)-3-oxo-3,7-dihydroimidazo[1,2-a]pyrazin-6-yl trifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-benzyl-2-(4-hydroxybenzyl)-3-oxo-3,7-dihydroimidazo[1,2-a]pyrazin-6-yl trifluoromethanesulfonate

There total 3 articles about 8-benzyl-2-(4-hydroxybenzyl)-3-oxo-3,7-dihydroimidazo[1,2-a]pyrazin-6-yl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

5-amino-6-benzyl-2-O-trifluoromethanesulfonyloxypyrazine (853941-51-2) + C11H10O4 (199446-76-9) → 8-benzyl-2-(4-hydroxybenzyl)-3-oxo-3,7-dihydroimidazo[1,2-a]pyrazin-6-yl trifluoromethanesulfonate (1268631-67-9)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; at 80 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.tet.2010.12.001

Reference yield:

5-N-(p-toluenesulfonyl)amide-6-benzyl-2-O-trifluoromethanesulfonyloxy-pyrazine (671240-61-2) → 8-benzyl-2-(4-hydroxybenzyl)-3-oxo-3,7-dihydroimidazo[1,2-a]pyrazin-6-yl trifluoromethanesulfonate (1268631-67-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 0 °C

2: hydrogenchloride / 1,4-dioxane; water / 3 h / 80 °C / Inert atmosphere

With hydrogenchloride; sulfuric acid; In 1,4-dioxane; water;

DOI:10.1016/j.tet.2010.12.001

Reference yield:

C18H17N3O3S (671240-60-1) → 8-benzyl-2-(4-hydroxybenzyl)-3-oxo-3,7-dihydroimidazo[1,2-a]pyrazin-6-yl trifluoromethanesulfonate (1268631-67-9)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

2: sulfuric acid / 0 °C

3: hydrogenchloride / 1,4-dioxane; water / 3 h / 80 °C / Inert atmosphere

With hydrogenchloride; sulfuric acid; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; water;

DOI:10.1016/j.tet.2010.12.001

upstream raw materials:

5-amino-6-benzyl-2-O-trifluoromethanesulfonyloxypyrazine

C₁₁H₁₀O₄

C₁₈H₁₇N₃O₃S

5-N-(p-toluenesulfonyl)amide-6-benzyl-2-O-trifluoromethanesulfonyloxy-pyrazine

Downstream raw materials:

8-benzyl-6-(4-fluorophenyl)-2-(4-hydroxybenzylidene)-imidazo[1,2-a]pyrazin-3(2H)-one

8-benzyl-6-(4-(dimethylamino)phenyl)-2-(4-hydroxybenzylidene)imidazo[1,2-a]pyrazin-3(2H)-one

8-benzyl-2-(4-hydroxybenzylidene)-6-phenylimidazo[1,2-a]-pyrazin-3(2H)-one