(1R,2S,3S,5S,6R,7S)-4,10-dioxa-3-[3-methoxy-5-(2'-t-butyldimethylsilyloxyethanesulfanyl)-4-propoxy]-5-[(3',4',5')-trimethoxyphenyl]-tricyclo[5.2.1.0^2,6]dec-8-en-3-ol

Base Information

• Chemical Name: (1R,2S,3S,5S,6R,7S)-4,10-dioxa-3-[3-methoxy-5-(2'-t-butyldimethylsilyloxyethanesulfanyl)-4-propoxy]-5-[(3',4',5')-trimethoxyphenyl]-tricyclo[5.2.1.0^2,6]dec-8-en-3-ol
• CAS No.: 481725-17-1
• Molecular Formula: C₃₅H₅₀O₉SSi
• Molecular Weight: 674.928

Synonyms:(1R,2S,3S,5S,6R,7S)-4,10-dioxa-3-[3-methoxy-5-(2'-t-butyldimethylsilyloxyethanesulfanyl)-4-propoxy]-5-[(3',4',5')-trimethoxyphenyl]-tricyclo[5.2.1.0^2,6]dec-8-en-3-ol

Chemical Property of (1R,2S,3S,5S,6R,7S)-4,10-dioxa-3-[3-methoxy-5-(2'-t-butyldimethylsilyloxyethanesulfanyl)-4-propoxy]-5-[(3',4',5')-trimethoxyphenyl]-tricyclo[5.2.1.0^2,6]dec-8-en-3-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2S,3S,5S,6R,7S)-4,10-dioxa-3-[3-methoxy-5-(2'-t-butyldimethylsilyloxyethanesulfanyl)-4-propoxy]-5-[(3',4',5')-trimethoxyphenyl]-tricyclo[5.2.1.0^2,6]dec-8-en-3-ol

There total 10 articles about (1R,2S,3S,5S,6R,7S)-4,10-dioxa-3-[3-methoxy-5-(2'-t-butyldimethylsilyloxyethanesulfanyl)-4-propoxy]-5-[(3',4',5')-trimethoxyphenyl]-tricyclo[5.2.1.0^2,6]dec-8-en-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

(1R,2S,5S,6R,7S)-5-[(3',4',5')-trimethoxyphenyl]-4,10-dioxatricyclo[5.2.1.02,6]dec-8-en-3-one (481725-16-0) + 1-bromo-3-methoxy-4-propoxy-5-(2'-tert-butyldimethylsilyloxyethanesulfanyl)benzene (481725-11-5) → (1R,2S,3S,5S,6R,7S)-4,10-dioxa-3-[3-methoxy-5-(2'-t-butyldimethylsilyloxyethanesulfanyl)-4-propoxy]-5-[(3',4',5')-trimethoxyphenyl]-tricyclo[5.2.1.02,6]dec-8-en-3-ol (481725-17-1)

Guidance literature:

1-bromo-3-methoxy-4-propoxy-5-(2'-tert-butyldimethylsilyloxyethanesulfanyl)benzene; With tert.-butyl lithium; In pentane; at -78 ℃; for 0.5h;

(1R,2S,5S,6R,7S)-5-[(3',4',5')-trimethoxyphenyl]-4,10-dioxatricyclo[5.2.1.0^2,6]dec-8-en-3-one; In tetrahydrofuran; pentane; at -78 ℃; for 0.5h;

DOI:10.1016/S0957-4166(02)00334-8

Reference yield:

5-iodovaniline (5438-36-8) → (1R,2S,3S,5S,6R,7S)-4,10-dioxa-3-[3-methoxy-5-(2'-t-butyldimethylsilyloxyethanesulfanyl)-4-propoxy]-5-[(3',4',5')-trimethoxyphenyl]-tricyclo[5.2.1.02,6]dec-8-en-3-ol (481725-17-1)

Guidance literature:

Multi-step reaction with 7 steps

1.1: 96 percent / cesium carbonate / dimethylformamide / 2 h / 50 °C

2.1: 91 percent / 2-methyl-2-butene; aq. sodium chlorite; NaH₂PO₄ / 2-methyl-propan-2-ol / 4 h / 20 °C

3.1: oxalyl chloride / dimethylformamide; CH₂Cl₂ / 18 h / 20 °C

4.1: 1.6 g / 2-mercaptopyridine oxide sodium salt; BrCCl₃; AIBN / 0.08 h / Heating

5.1: 77 percent / copper bronze / dimethylformamide / 20 h / 100 °C

6.1: 92 percent / imidazole / dimethylformamide / 20 °C

7.1: t-BuLi / pentane / 0.5 h / -78 °C

7.2: 53 percent / pentane; tetrahydrofuran / 0.5 h / -78 °C

With 1H-imidazole; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); Bromotrichloromethane; tert.-butyl lithium; 2-mercaptopyridine-1-oxide sodium salt; copper; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol; pentane;

DOI:10.1016/S0957-4166(02)00334-8

Reference yield:

1-bromo-3,4,5-trimethoxybenzene (2675-79-8) → (1R,2S,3S,5S,6R,7S)-4,10-dioxa-3-[3-methoxy-5-(2'-t-butyldimethylsilyloxyethanesulfanyl)-4-propoxy]-5-[(3',4',5')-trimethoxyphenyl]-tricyclo[5.2.1.02,6]dec-8-en-3-ol (481725-17-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: t-BuLi / pentane; diethyl ether / 1 h / -78 °C

1.2: ClTi(O-i-Pr)3 / diethyl ether; pentane; hexane / -40 - 0 °C

1.3: 91 percent / tetrahydrofuran; diethyl ether; various solvents / 4.5 h / 0 - 20 °C

2.1: 78 percent / 4 Angstroem molecular sieves; 4-methoxymorpholine N-oxide; tetrapropylammonium perruthenate / CH₂Cl₂ / 5 h / 20 °C

3.1: t-BuLi / pentane / 0.5 h / -78 °C

3.2: 53 percent / pentane; tetrahydrofuran / 0.5 h / -78 °C

With tetrapropylammonium perruthennate; NMO; 4 A molecular sieve; tert.-butyl lithium; In diethyl ether; dichloromethane; pentane;

DOI:10.1016/S0957-4166(02)00334-8

upstream raw materials:

(1R,2S,5S,6R,7S)-5-[(3',4',5')-trimethoxyphenyl]-4,10-dioxatricyclo[5.2.1.0^2,6]dec-8-en-3-one

1-bromo-3-methoxy-4-propoxy-5-(2'-tert-butyldimethylsilyloxyethanesulfanyl)benzene

5-iodovaniline

1-bromo-3,4,5-trimethoxybenzene

Downstream raw materials:

(2S,5S)-2-(3',4',5'-trimethoxyphenyl)-5-[3-methoxy-5-(2'-t-butyldimethylsilyloxyethanesulfanyl)-4-propoxyphenyl]tetrahydrofuran

(2S,5S)-2-(3',4',5'-trimethoxyphenyl)-5-[3-methoxy-5-(2'-t-butyldimethylsilyloxyethanesulfanyl)-4-propoxyphenyl]-2,5-dihydrofuran

(2S,5S)-2-(3',4',5'-trimethoxyphenyl)-5-[3-methoxy-5-(2'-t-butyldimethylsilyloxyethanesulfonyl)-4-propoxyphenyl]tetrahydrofuran

MK 287

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 481725-17-1 (1R,2S,3S,5S,6R,7S)-4,10-dioxa-3-[3-methoxy-5-(2'-t-butyldimethylsilyloxyethanesulfanyl)-4-propoxy]-5-[(3',4',5')-trimethoxyphenyl]-tricyclo[5.2.1.0^2,6]dec-8-en-3-ol

Send

Send

Metric Ton KG G Pound L ML

Send

Send