2-((4aR,8R,9aR)-6-(phenylcarbamoyl)-8-(pyrrolidine-1-carbonyl)-4a,6,7,8,9,9a-hexahydroindolo[1,14-fg]quinolin-1(4H)-yl)ethylmethanesulfonate

Base Information

Chemical Name:2-((4aR,8R,9aR)-6-(phenylcarbamoyl)-8-(pyrrolidine-1-carbonyl)-4a,6,7,8,9,9a-hexahydroindolo[1,14-fg]quinolin-1(4H)-yl)ethylmethanesulfonate
CAS No.:1624289-37-7
Molecular Formula:C₂₉H₃₄N₄O₅S
Molecular Weight:550.679
Hs Code.:

2-((4aR,8R,9aR)-6-(phenylcarbamoyl)-8-(pyrrolidine-1-carbonyl)-4a,6,7,8,9,9a-hexahydroindolo[1,14-fg]quinolin-1(4H)-yl)ethylmethanesulfonate

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Chemical Property of 2-((4aR,8R,9aR)-6-(phenylcarbamoyl)-8-(pyrrolidine-1-carbonyl)-4a,6,7,8,9,9a-hexahydroindolo[1,14-fg]quinolin-1(4H)-yl)ethylmethanesulfonate

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Technology Process of 2-((4aR,8R,9aR)-6-(phenylcarbamoyl)-8-(pyrrolidine-1-carbonyl)-4a,6,7,8,9,9a-hexahydroindolo[1,14-fg]quinolin-1(4H)-yl)ethylmethanesulfonate

There total 7 articles about 2-((4aR,8R,9aR)-6-(phenylcarbamoyl)-8-(pyrrolidine-1-carbonyl)-4a,6,7,8,9,9a-hexahydroindolo[1,14-fg]quinolin-1(4H)-yl)ethylmethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1624289-36-6
(4aR,8R,9aR)-1-(3-hydroxyethyl)-N-phenyl-8-(pyrrolidine-1-carbonyl)-4,4a,7,8,9,9a-hexahydroindolo[1,14-fg]quinoline-6(1H)-carboxamide

: 124-63-0
methanesulfonyl chloride

: 1624289-37-7
2-((4aR,8R,9aR)-6-(phenylcarbamoyl)-8-(pyrrolidine-1-carbonyl)-4a,6,7,8,9,9a-hexahydroindolo[1,14-fg]quinolin-1(4H)-yl)ethylmethanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 4h;
DOI:10.1002/cmdc.201402055

Reference yield:

: 1624289-35-5
isopropyl 2-((4aR,8R,9aR)-6-(phenylcarbamoyl)-8-(pyrrolidine-1-carbonyl)-4a,6,7,8,9,9a-hexahydroindolo[1,14-fg]quinolin-1(4H)-yl)acetate

: 1624289-37-7
2-((4aR,8R,9aR)-6-(phenylcarbamoyl)-8-(pyrrolidine-1-carbonyl)-4a,6,7,8,9,9a-hexahydroindolo[1,14-fg]quinolin-1(4H)-yl)ethylmethanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium borohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 4 h / 0 - 20 °C

With lithium borohydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1002/cmdc.201402055

Reference yield:

: 103-71-9
phenyl isocyanate

: 1624289-37-7
2-((4aR,8R,9aR)-6-(phenylcarbamoyl)-8-(pyrrolidine-1-carbonyl)-4a,6,7,8,9,9a-hexahydroindolo[1,14-fg]quinolin-1(4H)-yl)ethylmethanesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1: dichloromethane / 20 °C

2: sodium hydroxide / tetrahydrofuran; water / 2 h / 20 °C

3: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 20 °C

4: sodium hydroxide; tetra-(n-butyl)ammonium iodide / dichloromethane / 0 - 20 °C

5: lithium borohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

6: triethylamine / dichloromethane / 4 h / 0 - 20 °C

With lithium borohydride; tetra-(n-butyl)ammonium iodide; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1002/cmdc.201402055