N-(5-bromo-thiazol-2-yl)-3-cyclopentyl-2(R)-(4-methanesulfonyl-phenyl)-propionamide

Base Information

• Chemical Name: N-(5-bromo-thiazol-2-yl)-3-cyclopentyl-2(R)-(4-methanesulfonyl-phenyl)-propionamide
• CAS No.: 588939-98-4
• Molecular Formula: C₁₈H₂₁BrN₂O₃S₂
• Molecular Weight: 457.412
• Mol file: 588939-98-4.mol

Synonyms:N-(5-bromo-thiazol-2-yl)-3-cyclopentyl-2(R)-(4-methanesulfonyl-phenyl)-propionamide

Chemical Property of N-(5-bromo-thiazol-2-yl)-3-cyclopentyl-2(R)-(4-methanesulfonyl-phenyl)-propionamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(5-bromo-thiazol-2-yl)-3-cyclopentyl-2(R)-(4-methanesulfonyl-phenyl)-propionamide

There total 2 articles about N-(5-bromo-thiazol-2-yl)-3-cyclopentyl-2(R)-(4-methanesulfonyl-phenyl)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

3-cyclopentyl-2-(4-methanesulfonyl-phenyl)propionic acid (300354-95-4) + oxalyl dichloride (79-37-8) + 5-bromothiazol-2-amine hydrobromide (61296-22-8) → N-(5-bromo-thiazol-2-yl)-3-cyclopentyl-2(R)-(4-methanesulfonyl-phenyl)-propionamide (588939-98-4)

Guidance literature:

With triethylamine; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

5-bromo-2-aminothiazole (3034-22-8) + 3-cyclopentyl-2-(4-methanesulfonyl-phenyl)propionic acid (300354-95-4) → N-(5-bromo-thiazol-2-yl)-3-cyclopentyl-2(R)-(4-methanesulfonyl-phenyl)-propionamide (588939-98-4)

Guidance literature:

3-cyclopentyl-2-(4-methanesulfonyl-phenyl)propionic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 25 ℃; for 0.666667h; Inert atmosphere;

5-bromo-2-aminothiazole; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; at 25 ℃; for 17h; Inert atmosphere;

DOI:10.1021/jm3008689

upstream raw materials:

3-cyclopentyl-2-(4-methanesulfonyl-phenyl)propionic acid

oxalyl dichloride

5-bromothiazol-2-amine hydrobromide

5-bromo-2-aminothiazole