N-(2-butyl-3-(4-(3-chloropropoxy)benzoyl)benzofuran-5-yl)methanesulfonamide

Base Information

• Chemical Name: N-(2-butyl-3-(4-(3-chloropropoxy)benzoyl)benzofuran-5-yl)methanesulfonamide
• CAS No.: 1310430-05-7
• Molecular Formula: C₂₃H₂₆ClNO₅S
• Molecular Weight: 463.982
• Mol file: 1310430-05-7.mol

Synonyms:N-(2-butyl-3-(4-(3-chloropropoxy)benzoyl)benzofuran-5-yl)methanesulfonamide

Chemical Property of N-(2-butyl-3-(4-(3-chloropropoxy)benzoyl)benzofuran-5-yl)methanesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-butyl-3-(4-(3-chloropropoxy)benzoyl)benzofuran-5-yl)methanesulfonamide

There total 7 articles about N-(2-butyl-3-(4-(3-chloropropoxy)benzoyl)benzofuran-5-yl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(4-(3-chloropropoxy)phenyl)(5-amino-2-butylbenzofuran-3-yl)methanone (1309476-89-8) + methanesulfonyl chloride (124-63-0) → N-(2-butyl-3-(4-(3-chloropropoxy)benzoyl)benzofuran-5-yl)methanesulfonamide (1310430-05-7)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; at 35 ℃; for 6h;

DOI:10.1002/jccs.201190133

Reference yield:

N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide (437652-07-8) + 4-(3-chloropropoxy)benzoic acid chloride (65136-48-3) → N-(2-butyl-3-(4-(3-chloropropoxy)benzoyl)benzofuran-5-yl)methanesulfonamide (1310430-05-7)

Guidance literature:

N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide; 4-(3-chloropropoxy)benzoic acid chloride; iron(III) chloride; In dichloromethane; at 5 - 45 ℃;

With water; In dichloromethane; at 40 - 45 ℃; for 1h; Product distribution / selectivity;

Reference yield:

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran (141645-16-1) → N-(2-butyl-3-(4-(3-chloropropoxy)benzoyl)benzofuran-5-yl)methanesulfonamide (1310430-05-7)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / butanone / 4 h / 81 - 82 °C

2: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 50 °C / 3750.38 Torr

3: pyridine / dichloromethane / 15 °C

With pyridine; hydrogen; potassium carbonate; palladium 10% on activated carbon; In ethanol; dichloromethane; butanone;

upstream raw materials:

(4-(3-chloropropoxy)phenyl)(5-amino-2-butylbenzofuran-3-yl)methanone

methanesulfonyl chloride

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide

Downstream raw materials:

dronedarone

dronedarone hydrochloride