3-(1-bromoethyl)phenyl ethyl(methyl)carbamate

Base Information

• Chemical Name: 3-(1-bromoethyl)phenyl ethyl(methyl)carbamate
• CAS No.: 1392101-39-1
• Molecular Formula: C₁₂H₁₆BrNO₂
• Molecular Weight: 286.169
• Mol file: 1392101-39-1.mol

Synonyms:3-(1-bromoethyl)phenyl ethyl(methyl)carbamate

Chemical Property of 3-(1-bromoethyl)phenyl ethyl(methyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of 3-(1-bromoethyl)phenyl ethyl(methyl)carbamate

There total 1 articles about 3-(1-bromoethyl)phenyl ethyl(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.5%

rac-1-(N-ethyl-N-methylaminocarbonyloxy)-3-(1-hydroxyethyl)benzene (1222073-98-4) → 3-(1-bromoethyl)phenyl ethyl(methyl)carbamate (1392101-39-1)

Guidance literature:

rac-1-(N-ethyl-N-methylaminocarbonyloxy)-3-(1-hydroxyethyl)benzene; With phosphorus tribromide; In dichloromethane; at 0 - 5 ℃; for 2.5h;

In dichloromethane; water; at 18 ℃; for 0.5h;

Reference yield: 87.0%

3-(1-bromoethyl)phenyl ethyl(methyl)carbamate (1392101-39-1) + S,S-diphenylsulphoximine (22731-83-5) → (S)-3-(1-((oxodiphenyl-λ6-sulfaneylidene)amino)ethyl)phenyl ethyl(methyl)carbamate

Guidance literature:

With copper(I) thiophene-2-carboxylate; C₉₅H₁₁₈N₃O₂P; caesium carbonate; In diethyl ether; at 20 ℃; for 72h; enantioselective reaction; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1021/jacs.1c07726

Reference yield: 71.2%

3-(1-bromoethyl)phenyl ethyl(methyl)carbamate (1392101-39-1) + dimethyl amine (124-40-3) → rac-rivastigmine (105601-20-5,415973-05-6)

Guidance literature:

3-(1-bromoethyl)phenyl ethyl(methyl)carbamate; dimethyl amine; In methanol; at 26 - 28 ℃; for 16 - 20h;

With hydrogenchloride; In water; at 12 - 15 ℃;

With sodium carbonate; In water; at 15 - 20 ℃; pH=2 - 11; Product distribution / selectivity;

upstream raw materials:

rac-1-(N-ethyl-N-methylaminocarbonyloxy)-3-(1-hydroxyethyl)benzene

Downstream raw materials:

rac-rivastigmine