N-(2,6-diisopropylphenyl)-6-((5-(hydroxymethyl)benzo[d]oxazol-2-yl)thio)hexanamide

Base Information

Chemical Name:N-(2,6-diisopropylphenyl)-6-((5-(hydroxymethyl)benzo[d]oxazol-2-yl)thio)hexanamide
CAS No.:213684-92-5
Molecular Formula:C₂₆H₃₄N₂O₃S
Molecular Weight:454.634
Hs Code.:

Synonyms:N-(2,6-diisopropylphenyl)-6-((5-(hydroxymethyl)benzo[d]oxazol-2-yl)thio)hexanamide

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Chemical Property of N-(2,6-diisopropylphenyl)-6-((5-(hydroxymethyl)benzo[d]oxazol-2-yl)thio)hexanamide

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Technology Process of N-(2,6-diisopropylphenyl)-6-((5-(hydroxymethyl)benzo[d]oxazol-2-yl)thio)hexanamide

There total 9 articles about N-(2,6-diisopropylphenyl)-6-((5-(hydroxymethyl)benzo[d]oxazol-2-yl)thio)hexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 213684-91-4
2-((6-((2,6-diisopropylphenyl)amino)-6-oxohexyl)thio)benzo[d]oxazole-5-carboxylic acid

: 213684-92-5
N-(2,6-diisopropylphenyl)-6-((5-(hydroxymethyl)benzo[d]oxazol-2-yl)thio)hexanamide

Guidance literature:: 2-((6-((2,6-diisopropylphenyl)amino)-6-oxohexyl)thio)benzo[d]oxazole-5-carboxylic acid; With triethylamine; methyl chloroformate; In tetrahydrofuran; at 0 ℃; for 0.5h;

With sodium tetrahydroborate; In water; at 20 ℃; for 0.5h;
DOI:10.1016/j.bmc.2018.06.024

Reference yield:

: 213684-90-3
methyl 2-((6-((2,6-diisopropylphenyl)amino)-6-oxohexyl)thio)benzo[d]oxazole-5-carboxylate

: 213684-92-5
N-(2,6-diisopropylphenyl)-6-((5-(hydroxymethyl)benzo[d]oxazol-2-yl)thio)hexanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide / tetrahydrofuran; water; tert-butyl alcohol / 12 h / 20 °C

2.1: methyl chloroformate; triethylamine / tetrahydrofuran / 0.5 h / 0 °C

2.2: 0.5 h / 20 °C

With triethylamine; methyl chloroformate; lithium hydroxide; In tetrahydrofuran; water; tert-butyl alcohol;
DOI:10.1016/j.bmc.2018.06.024

Reference yield:

: 199592-72-8
6-bromo-N-(2,6-diisopropylphenyl)hexanamide

: 213684-92-5
N-(2,6-diisopropylphenyl)-6-((5-(hydroxymethyl)benzo[d]oxazol-2-yl)thio)hexanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; 18-crown-6 ether / N,N-dimethyl-formamide / 2 h / 80 °C

2.1: lithium hydroxide / tetrahydrofuran; water; tert-butyl alcohol / 12 h / 20 °C

3.1: methyl chloroformate; triethylamine / tetrahydrofuran / 0.5 h / 0 °C

3.2: 0.5 h / 20 °C

With 18-crown-6 ether; potassium carbonate; triethylamine; methyl chloroformate; lithium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.bmc.2018.06.024