N-(2,6-diisopropylphenyl)-6-((5-((N,N-dimethylamino)methyl)benzo[d]oxazol-2-yl)thio)hexanamide

Base Information

Chemical Name:N-(2,6-diisopropylphenyl)-6-((5-((N,N-dimethylamino)methyl)benzo[d]oxazol-2-yl)thio)hexanamide
CAS No.:213684-93-6
Molecular Formula:C₂₈H₃₉N₃O₂S
Molecular Weight:481.703
Hs Code.:

Synonyms:N-(2,6-diisopropylphenyl)-6-((5-((N,N-dimethylamino)methyl)benzo[d]oxazol-2-yl)thio)hexanamide

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Chemical Property of N-(2,6-diisopropylphenyl)-6-((5-((N,N-dimethylamino)methyl)benzo[d]oxazol-2-yl)thio)hexanamide

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Technology Process of N-(2,6-diisopropylphenyl)-6-((5-((N,N-dimethylamino)methyl)benzo[d]oxazol-2-yl)thio)hexanamide

There total 10 articles about N-(2,6-diisopropylphenyl)-6-((5-((N,N-dimethylamino)methyl)benzo[d]oxazol-2-yl)thio)hexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 213684-92-5
N-(2,6-diisopropylphenyl)-6-((5-(hydroxymethyl)benzo[d]oxazol-2-yl)thio)hexanamide

: 124-40-3
dimethyl amine

: 213684-93-6
N-(2,6-diisopropylphenyl)-6-((5-((N,N-dimethylamino)methyl)benzo[d]oxazol-2-yl)thio)hexanamide

Guidance literature:: N-(2,6-diisopropylphenyl)-6-((5-(hydroxymethyl)benzo[d]oxazol-2-yl)thio)hexanamide; With dmap; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; at 0 ℃; for 0.5h;

dimethyl amine; In tetrahydrofuran; water; for 1h; Reflux;
DOI:10.1016/j.bmc.2018.06.024

Reference yield:

: 213684-90-3
methyl 2-((6-((2,6-diisopropylphenyl)amino)-6-oxohexyl)thio)benzo[d]oxazole-5-carboxylate

: 213684-93-6
N-(2,6-diisopropylphenyl)-6-((5-((N,N-dimethylamino)methyl)benzo[d]oxazol-2-yl)thio)hexanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydroxide / tetrahydrofuran; water; tert-butyl alcohol / 12 h / 20 °C

2.1: methyl chloroformate; triethylamine / tetrahydrofuran / 0.5 h / 0 °C

2.2: 0.5 h / 20 °C

3.1: dmap; triethylamine; methanesulfonyl chloride / tetrahydrofuran / 0.5 h / 0 °C

3.2: 1 h / Reflux

With dmap; methanesulfonyl chloride; triethylamine; methyl chloroformate; lithium hydroxide; In tetrahydrofuran; water; tert-butyl alcohol;
DOI:10.1016/j.bmc.2018.06.024

Reference yield:

: 199592-72-8
6-bromo-N-(2,6-diisopropylphenyl)hexanamide

: 213684-93-6
N-(2,6-diisopropylphenyl)-6-((5-((N,N-dimethylamino)methyl)benzo[d]oxazol-2-yl)thio)hexanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; 18-crown-6 ether / N,N-dimethyl-formamide / 2 h / 80 °C

2.1: lithium hydroxide / tetrahydrofuran; water; tert-butyl alcohol / 12 h / 20 °C

3.1: methyl chloroformate; triethylamine / tetrahydrofuran / 0.5 h / 0 °C

3.2: 0.5 h / 20 °C

4.1: dmap; triethylamine; methanesulfonyl chloride / tetrahydrofuran / 0.5 h / 0 °C

4.2: 1 h / Reflux

With dmap; 18-crown-6 ether; potassium carbonate; methanesulfonyl chloride; triethylamine; methyl chloroformate; lithium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.bmc.2018.06.024