N-[7-phenoxy-2-(1H-indenyl)]methyl-O-(tetrahydropyran-2-yl)hydroxylamine

Base Information

Chemical Name:N-[7-phenoxy-2-(1H-indenyl)]methyl-O-(tetrahydropyran-2-yl)hydroxylamine
CAS No.:131662-01-6
Molecular Formula:C₂₁H₂₃NO₃
Molecular Weight:337.419
Hs Code.:

Synonyms:N-[7-phenoxy-2-(1H-indenyl)]methyl-O-(tetrahydropyran-2-yl)hydroxylamine

Suppliers and Price of N-[7-phenoxy-2-(1H-indenyl)]methyl-O-(tetrahydropyran-2-yl)hydroxylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[7-phenoxy-2-(1H-indenyl)]methyl-O-(tetrahydropyran-2-yl)hydroxylamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[7-phenoxy-2-(1H-indenyl)]methyl-O-(tetrahydropyran-2-yl)hydroxylamine

There total 6 articles about N-[7-phenoxy-2-(1H-indenyl)]methyl-O-(tetrahydropyran-2-yl)hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 6723-30-4
O-2-tetrahydro-2H-pyranhydroxylamine

: 131661-99-9
2-bromomethyl-7-phenoxy-1H-indene

: 131662-01-6
N-[7-phenoxy-2-(1H-indenyl)]methyl-O-(tetrahydropyran-2-yl)hydroxylamine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1248/cpb.46.966

Reference yield:

: 62803-52-5
4-phenoxy-2,3-dihydroinden-1-one

: 131662-01-6
N-[7-phenoxy-2-(1H-indenyl)]methyl-O-(tetrahydropyran-2-yl)hydroxylamine

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) BF₃*Et₂O, 2.) N,N-diisopropylethylamine / 1.) CH₂Cl₂, 0 deg C, 2.) CH₂Cl₂, from -78 to -10 deg C

2: NaBH₄ / methanol / 0 °C

3: 2N aq. HCl / dioxane / 70 °C

4: 100 percent / NaBH₄ / methanol; tetrahydrofuran / 0.17 h / 0 °C

5: 93.9 percent / 48percent aq. HBr / diethyl ether; hexane / 1 h / 0 - 20 °C

6: 95 percent / K₂CO₃ / dimethylformamide / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; boron trifluoride diethyl etherate; hydrogen bromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; hexane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.966

Reference yield:

: 131661-70-6
7-Phenoxy-1H-indene-2-carbaldehyde

: 131662-01-6
N-[7-phenoxy-2-(1H-indenyl)]methyl-O-(tetrahydropyran-2-yl)hydroxylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / NaBH₄ / methanol; tetrahydrofuran / 0.17 h / 0 °C

2: 93.9 percent / 48percent aq. HBr / diethyl ether; hexane / 1 h / 0 - 20 °C

3: 95 percent / K₂CO₃ / dimethylformamide / Ambient temperature

With sodium tetrahydroborate; hydrogen bromide; potassium carbonate; In tetrahydrofuran; methanol; diethyl ether; hexane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.966