dibenzyl 4,10-bis(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,7-dicarboxylate

Base Information

• Chemical Name: dibenzyl 4,10-bis(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,7-dicarboxylate
• CAS No.: 187240-78-4
• Molecular Formula: C₃₆H₅₂N₄O₈
• Molecular Weight: 668.831
• Mol file: 187240-78-4.mol

Synonyms:dibenzyl 4,10-bis(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,7-dicarboxylate

Chemical Property of dibenzyl 4,10-bis(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,7-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dibenzyl 4,10-bis(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,7-dicarboxylate

There total 8 articles about dibenzyl 4,10-bis(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,7-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

bromoacetic acid tert-butyl ester (5292-43-3) + 1,4,7,10-tetraaza-cyclododecane-1,7-dicarboxylic acid dibenzyl ester (162148-45-0) → dibenzyl 4,10-bis(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,7-dicarboxylate (187240-78-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; for 0.5h; Reflux;

DOI:10.3390/molecules25081959

Reference yield: 92.0%

3-methyl-N-(3-methylbutyl)-1-butanamine (544-00-3) + bromoacetic acid tert-butyl ester (5292-43-3) + 1,4,7,10-tetraaza-cyclododecane-1,7-dicarboxylic acid dibenzyl ester (162148-45-0) → dibenzyl 4,10-bis(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,7-dicarboxylate (187240-78-4)

Guidance literature:

In sodium carbonate; acetonitrile;

Reference yield: 84.0%

bromoacetic acid tert-butyl ester (5292-43-3) + 4,10-bis((benzyloxy)carbonyl)-4,10-diaza-1,7-diazoniacyclododecane-1,7-diium chloride → dibenzyl 4,10-bis(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,7-dicarboxylate (187240-78-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 60 ℃; for 12h;

DOI:10.1039/c4cc09759a

upstream raw materials:

bromoacetic acid tert-butyl ester

1,4,7,10-tetraaza-cyclododecane-1,7-dicarboxylic acid dibenzyl ester

1,4,7,10-tetraazacyclododecan

3-methyl-N-(3-methylbutyl)-1-butanamine

Downstream raw materials:

1,4,7,10-tetraazacyclododecane-1,7-diacetic acid

(7-tert-butoxycarbonylmethyl-1,4,7,10-tetraaza-cyclododec-1-yl)-acetic acid tert-butyl ester

4,10-bis-(carbo-tert-butoxymethyl)-14-(4-nitrobenzyl)-1,4,7,10-tetraazabicyclo[5. 5.3]pentadecane

4,10-bis-(carbo-tert-butoxymethyl)-14-(4-aminobenzyl)-1,4,7,10-tetraazabicyclo[ 5.5.3]pentadecane