N⁹-{(2R,6S)-6-hydroxymethyl-4-tritylmorpholin-2yl}-N²-(phenoxyacetyl)guanine

Base Information

Chemical Name:N⁹-{(2R,6S)-6-hydroxymethyl-4-tritylmorpholin-2yl}-N²-(phenoxyacetyl)guanine
CAS No.:1362664-36-5
Molecular Formula:C₃₇H₃₄N₆O₅
Molecular Weight:642.714
Hs Code.:

N<sup>9</sup>-{(2R,6S)-6-hydroxymethyl-4-tritylmorpholin-2yl}-N<sup>2</sup>-(phenoxyacetyl)guanine

Synonyms:N⁹-{(2R,6S)-6-hydroxymethyl-4-tritylmorpholin-2yl}-N²-(phenoxyacetyl)guanine

Suppliers and Price of N⁹-{(2R,6S)-6-hydroxymethyl-4-tritylmorpholin-2yl}-N²-(phenoxyacetyl)guanine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N⁹-{(2R,6S)-6-hydroxymethyl-4-tritylmorpholin-2yl}-N²-(phenoxyacetyl)guanine

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Technology Process of N⁹-{(2R,6S)-6-hydroxymethyl-4-tritylmorpholin-2yl}-N²-(phenoxyacetyl)guanine

There total 4 articles about N⁹-{(2R,6S)-6-hydroxymethyl-4-tritylmorpholin-2yl}-N²-(phenoxyacetyl)guanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1362664-34-3
N⁹-{(2R,6S)-6-(hydroxymethyl)morpholin-2-yl}-N²-(phenoxyacetyl)guanine p-toluenesulfonate

: 76-83-5
trityl chloride

: 1362664-36-5
N⁹-{(2R,6S)-6-hydroxymethyl-4-tritylmorpholin-2yl}-N²-(phenoxyacetyl)guanine

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1h; Cooling with ice;

Reference yield:

: 701-99-5
Phenoxyacetyl chloride

: 1362664-36-5
N⁹-{(2R,6S)-6-hydroxymethyl-4-tritylmorpholin-2yl}-N²-(phenoxyacetyl)guanine

Guidance literature:: Multi-step reaction with 3 steps

1.1: chloro-trimethyl-silane; pyridine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

1.2: 3 h / Cooling with ice

2.1: hydrogenchloride; sodium periodate / methanol; water / 3 h / 20 °C / Cooling with ice

2.2: 0.33 h / Cooling with ice

2.3: 4 °C

3.1: triethylamine / dichloromethane / 1 h / 20 °C / Cooling with ice

With pyridine; hydrogenchloride; sodium periodate; chloro-trimethyl-silane; triethylamine; In methanol; dichloromethane; water;

Reference yield:

: 119824-66-7
N²-(phenoxyacetyl)guanosine

: 1362664-36-5
N⁹-{(2R,6S)-6-hydroxymethyl-4-tritylmorpholin-2yl}-N²-(phenoxyacetyl)guanine

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; sodium periodate / methanol; water / 3 h / 20 °C / Cooling with ice

1.2: 0.33 h / Cooling with ice

1.3: 4 °C

2.1: triethylamine / dichloromethane / 1 h / 20 °C / Cooling with ice

With hydrogenchloride; sodium periodate; triethylamine; In methanol; dichloromethane; water;