4-HYDROXY-BENZAMIDINE

Base Information

• Chemical Name: 4-HYDROXY-BENZAMIDINE
• CAS No.: 15535-98-5
• Molecular Formula: C7H8 N2 O
• Molecular Weight: 136.153
• Hs Code.: 2921420090
• Mol file: 15535-98-5.mol

Synonyms:Benzamidine,p-hydroxy- (8CI); 4-Amidinophenol; 4-Hydroxybenzamidine; p-Amidinophenol;p-Hydroxybenzamidine

Chemical Property of 4-HYDROXY-BENZAMIDINE

Chemical Property:

• PSA: 70.10000
• LogP: 1.47630
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Hydroxybenzimidamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-HYDROXY-BENZAMIDINE

There total 9 articles about 4-HYDROXY-BENZAMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Nα-Boc-D-Ala-OAm → Boc-(R)-Ala (3744-87-4,7764-95-6,15761-38-3) + p-hydroxybenzamidine (15535-98-5)

Guidance literature:

With water; at 25 ℃; pH=8; Kinetics; aq. buffer; Enzymatic reaction;

DOI:10.1248/cpb.58.484

Reference yield:

Nα-Boc-L-Ala-OAm → L-N-Boc-Ala (15761-38-3) + p-hydroxybenzamidine (15535-98-5)

Guidance literature:

With water; at 25 ℃; pH=8; Kinetics; aq. buffer; Enzymatic reaction;

DOI:10.1248/cpb.58.484

Reference yield:

4-cyanophenol (767-00-0) → p-hydroxybenzamidine (15535-98-5)

Guidance literature:

With ammonium thiocyanate; at 180 ℃;

DOI:10.1039/jr9470000390

upstream raw materials:

4-cyanophenol

4-hydroxybenzimidic acid methyl ester hydrochloride

4-Hydroxybenzimidsaeureethylester

N',4-dihydroxybenzamidine

Downstream raw materials:

N,N-dicyclohexylurea

Benzoic acid 4-carbamimidoyl-2-nitro-phenyl ester

Benzoic acid 2,6-dibromo-4-carbamimidoyl-phenyl ester

3-Amino-4-hydroxy-benzamidine; compound with methanesulfonic acid

Refernces

• 1、 Bauch, Eva,Reichmann, Debora,Mendel, Ralf-Rainer,Bittner, Florian,Manke, Anne-Marie,Kurz, Philipp,Girreser, Ulrich,Havemeyer, Antje,Clement, Bernd. "Electrochemical and mARC-catalyzed enzymatic reduction of para-substituted benzamidoximes: Consequences for the prodrug concept "amidoximes instead of amidines"". . p. 360 - 367. Retrieved 2015/02/05.
• 2、 Vanden Eynde, Jean Jacques,Mayence, Annie,Johnson, Melissa T.,Huang, Tien L.,Collins, Margaret S.,Rebholz, Sandra,Walzer, Peter D.,Cushion, Melanie T.,Donkor, Isaac O.. "Antitumor and anti-Pneumocystis carinii activities of novel bisbenzamidines". . p. 143 - 157. Retrieved 2007/10/03.