METHYL 4-HYDROXYBENZIMIDATE HYDRO-CHLORIDE

Base Information

• Chemical Name: METHYL 4-HYDROXYBENZIMIDATE HYDRO-CHLORIDE
• CAS No.: 57943-60-9
• Molecular Formula: C8H10ClNO2
• Molecular Weight: 187.626
• Mol file: 57943-60-9.mol

Synonyms:MHBI;WOOD'S REAGENT;METHYL P-HYROXYBENZIMIDATE HYDROCHLORIDE;METHYL 4-HYDROXYBENZIMIDATE HYDRO-CHLORIDE;methyl4-hydroxybenzimidateHCl;METHYL-P-HYDROXYBENZIMIDATEHYDROCHLORIDE

Chemical Property of METHYL 4-HYDROXYBENZIMIDATE HYDRO-CHLORIDE

Chemical Property:

• Melting Point: 174-180 °C (dec.)
• PSA: 53.31000
• LogP: 2.26570
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

Methyl-p-hydroxybenzimidatehydrochloride,98% 98% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of METHYL 4-HYDROXYBENZIMIDATE HYDRO-CHLORIDE

There total 2 articles about METHYL 4-HYDROXYBENZIMIDATE HYDRO-CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methanol (67-56-1) + 4-cyanophenol (767-00-0) → 4-hydroxybenzimidic acid methyl ester hydrochloride (57943-60-9)

Guidance literature:

With acetyl chloride; at 20 ℃;

DOI:10.1016/j.bmcl.2006.01.032

Reference yield:

4-cyanophenol (767-00-0) + acetyl chloride (75-36-5) → 4-hydroxybenzimidic acid methyl ester hydrochloride (57943-60-9)

Guidance literature:

In methanol; at 20 ℃; for 12h;

Reference yield: 99.0%

4-hydroxybenzimidic acid methyl ester hydrochloride (57943-60-9) → 1,2-dihydro-3,6-bis(4-hydroxyphenyl)-1,2,4,5-tetrazine

Guidance literature:

With hydrazine; In 1,4-dioxane; Heating;

DOI:10.1080/00397910008087126

upstream raw materials:

methanol

4-cyanophenol

acetyl chloride

Downstream raw materials:

4-(5'-methyl-1H-benzimidazol-2'-yl)phenol hydrochloride

4-(5'-chloro-1H-benzimidazol-2'-yl)phenol hydrochloride

4-<5'-(4''-methylpiperazin-1''-yl)-1H-benzimidazol-2'-yl>phenol hydrochloride

p-hydroxybenzamidine

Refernces

• 1、 -. "VASCULAR ADHESION PROTEIN-1 (VAP-1) MODULATORS AND THERAPEUTIC USES THEREOF". Paragraph 0289. . Retrieved 2020/01/24.
• 2、 -. "AMIDINE SUBSTITUTED BETA - LACTAM COMPOUNDS, THEIR PREPARATION AND USE AS ANTIBACTERIAL AGENTS". Paragraph 00264-00266. . Retrieved 2013/08/15.